Evidence map›Paper›PMID 33883825›Full record

ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2021

Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease.

Akiko Watanabe, Keiichi Ohata, Tsuyoshi Oikawa, Takeshi Sugaya, Masao Miyazaki, Hiroshi Satoh, Masaaki Katayama

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. A Review of Experimental Models of Feline Kidney Disease.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Akiko WatanabeGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Keiichi OhataGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Tsuyoshi OikawaGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Takeshi SugayaGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Masao MiyazakiGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Hiroshi SatohGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Masaaki KatayamaGraduate School of Veterinary Sciences, Iwate University (Watanabe) and Laboratory of Biomolecular Science, Department of Biological Chemistry and Food Sciences (Miyazaki), Division of Veterinary Pharmacology and Toxicity, Cooperative Department of Veterinary Medicine (Satoh), and Division of Companion Animal Surgery, Veterinary Teaching Hospital (Katayama, Watanabe), Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan; CMIC Holdings, Tokyo 113-0034, Japan (Ohata, Oikawa); Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan (Ohata, Sugaya).
Iwate University · JPOji Holdings (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urinary liver-type fatty acid-binding protein (uL-FABP) is a clinically useful biomarker for monitoring chronic kidney disease (CKD) in humans. However, long-term monitoring of uL-FABP in CKD cats has not been reported. The objective of this preliminary study was to investigate whether the urinary excretion of L-FABP could predict the deterioration of renal function in 2 CKD model cats. Urinary liver-type fatty acid-binding protein (uL-FABP) increased before standard renal biomarkers, including serum creatinine, blood urea nitrogen, and symmetric dimethylarginine, in 1 cat with deteriorating renal function, but remained low and relatively stable in another cat with stable renal function. Our results suggest that uL-FABP is a potential clinical biomarker for predicting the progression of CKD in cats, as it is in humans.

Indexed as

AnimalsBiomarkersCat DiseasesCatsFatty Acid-Binding ProteinsFemaleRenal Insufficiency, ChronicBiomarkersFatty Acid-Binding Proteins

Identifiers

PMID33883825
PMCPMC7995540
OpenAlexW3154853384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.