Evidence map›Paper›PMID 33883768›Full record

Trial reportGhana medical journal2020

Safety and efficacy of single-dose preoperative intravenous dexamethasone on post-operative nausea and vomiting following breast surgery at Korle-Bu Teaching Hospital.

Papa K G deGraft-Johnson, Robert Djagbletey, Henry K Baddoo, Ernest Aniteye, Raymond Essuman, George Aryee, Pokua Sarpong, Ebenezer O Darkwa

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ghana medical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Papa K G deGraft-JohnsonDepartment of Anaesthesia, Korle-Bu Teaching Hospital, Accra, Ghana.
Robert DjagbleteyDepartment of Anaesthesia, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Henry K BaddooDepartment of Anaesthesia, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Ernest AniteyeDepartment of Anaesthesia, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Raymond EssumanDepartment of Anaesthesia, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
George AryeeDepartment of Anaesthesia, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
Pokua SarpongDepartment of Anaesthesia, Korle-Bu Teaching Hospital, Accra, Ghana.
Ebenezer O DarkwaDepartment of Anaesthesia, University of Ghana Medical School, Korle-Bu, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDexamethasone has beneficial effects on postoperative nausea and vomiting, however, many clinicians have raised legitimate concerns regarding its effect on blood glucose concentrations. This study determined the safety and efficacy of a single pre-operative dose of dexamethasone for PONV prophylaxis in patients undergoing breast surgery.

designProspective, double-blind, placebo-controlled trial.

settingSurgical wards of the Korle-Bu Teaching Hospital, Accra, Ghana.

participantsThe study was conducted among breast surgery patients. They were consecutively recruited and randomized into two groups: dexamethasone (

interventionsPatients in the dexamethasone group received 8mg (2mls of 4mg/ml) dexamethasone while those in the placebo group received 2mls of saline intravenously. PONV impact scores and blood glucose levels were recorded at 4, 8 and 24 hours postoperatively.

main outcome measuresIncidence of PONV and blood glucose levels.

resultsThe incidence of postoperative nausea (PON) was lower in the dexamethasone group compared with the placebo group (12.8% vs. 29.8%;

conclusionA preoperative intravenous dexamethasone 8mg, reduces PON but not POV or PONV in breast surgery without clinically significant postoperative hyperglycemia.

fundingNon declared.

Indexed as

AdultAgedAntiemeticsBreast NeoplasmsDexamethasoneDouble-Blind MethodFemaleGhanaHospitals, TeachingHumansIncidenceMiddle AgedPostoperative Nausea and VomitingProspective StudiesTreatment OutcomeAntiemeticsDexamethasonebreast surgeryDexamethasonenauseapostoperativevomiting

Identifiers

PMID33883768
PMCPMC8042812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.