Evidence map›Paper›PMID 33883566›Full record

SynthesisScientific reports2021

Efficacy of induction regimens for cryptococcal meningitis in HIV-infected adults: a systematic review and network meta-analysis.

Chang-Hua Chen, Hua Li, Hsien-Meng Chen, Yu-Min Chen, Yu-Jun Chang, Pao-Yen Lin, Chih-Wei Hsu, Ping-Tao Tseng, Kai-Huang Lin, Yu-Kang Tu

Open access · goldAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Chang-Hua ChenDivision of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Hua Li *Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Hsien-Meng ChenDivision of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Yu-Min ChenDepartment of Pharmacy, Changhua Christian Hospital, Changhua, Taiwan.
Yu-Jun ChangEpidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua, Taiwan.
Pao-Yen LinDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Chih-Wei HsuDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Ping-Tao TsengWinShine Clinics in Specialty of Psychiatry, Kaohsiung City, Taiwan.
Kai-Huang LinDivision of Critical Care Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Yu-Kang TuInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. yukangtu@ntu.edu.tw.
Changhua Christian Hospital · TWChang Gung University · TWNational Cheng Kung University · TWNational Chung Hsing University · TWNational Taiwan University · TWNational Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptococcal meningitis (CM) is the most fatal adult meningitis in patients with human immunodeficiency virus (HIV). There is no conclusive evidence for the superiority of 1-week amphotericin B deoxycholate (AmphB) + flucytosine (5-FC) regimen over other antifungals in the management of HIV patients with CM (HIV-CM patients). We aimed to evaluate the differences in efficacy and tolerability of different antifungal agents in HIV-CM patients by conducting a current network meta-analysis NMA. Overall, 19 randomized controlled trials were included with 2642 participants. A regimen indicated a possibly lower early mortality rate, namely, AmphB + 5-FC + Azole (OR = 1.1E-12, 95% CIs = 1.3E-41 to 0.06) comparing to AmphB + 5-FC. The current NMA provides evidence that AmphB + 5-FC + Azole are superior to all the investigated treatments for induction regimen in HIV-CM patients.

Indexed as

AIDS-Related Opportunistic InfectionsAmphotericin BAntifungal AgentsDeoxycholic AcidDrug CombinationsFlucytosineHumansInduction ChemotherapyMeningitis, CryptococcalTreatment OutcomeAmphotericin Bamphotericin B, deoxycholate drug combinationAntifungal AgentsDeoxycholic AcidDrug CombinationsFlucytosine

Identifiers

PMID33883566
PMCPMC8060388
OpenAlexW3153744121

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.