ArticleScientific reports2021
Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Supracellular Mechanics and Counter-Rotational Bilateral Flows Orchestrate Posterior Morphogenesis.bioRxiv : the preprint server for biology · 2025Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Evolvability in vertebrate segmentation.Seminars in cell & developmental biology · 2025Review
- Start early and pack light: Collaborative adventures in theory and experiment.Seminars in cell & developmental biology · 2025Review
- The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High-Resolution Live Cell Microscopy.Small methods · 2025Article
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- A multi-tiered mechanical mechanism shapes the early neural plate.Nature communications · 2025Article
- Article
- The physical roles of different posterior tissues in zebrafish axis elongation.Nature communications · 2025Article
- Stochastic morphological swings inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Peeking into the future: inferring mechanics in dynamical tissues.Biochemical Society transactions · 2024Review
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- The TissueTractor, a device for applying large strains to tissues and cells for simultaneous high-resolution live cell microscopy.bioRxiv : the preprint server for biology · 2024Article
- Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: integrating viscous modeling and experimental approaches.Development (Cambridge, England) · 2024Article
- Conserved physical mechanisms of cell and tissue elongation.Development (Cambridge, England) · 2024Review
- Choice of friction coefficient deeply affects tissue behaviour in stochastic epithelial vertex models.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development.Nature cell biology · 2024Article
- Adherens junctions as molecular regulators of emergent tissue mechanics.Nature reviews. Molecular cell biology · 2024Review
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Shaping embryonic tissues into their functional morphologies requires cells to control the physical state of the tissue in space and time. While regional variations in cellular forces or cell proliferation have been typically assumed to be the main physical factors controlling tissue morphogenesis, recent experiments have revealed that spatial variations in the tissue physical (fluid/solid) state play a key role in shaping embryonic tissues. Here we theoretically study how the regional control of fluid and solid tissue states guides morphogenetic flows to shape the extending vertebrate body axis. Our results show that both the existence of a fluid-to-solid tissue transition along the anteroposterior axis and the tissue surface tension determine the shape of the tissue and its ability to elongate unidirectionally, with large tissue tensions preventing unidirectional elongation and promoting blob-like tissue expansions. We predict both the tissue morphogenetic flows and stresses that enable unidirectional axis elongation. Our results show the existence of a sharp transition in the structure of morphogenetic flows, from a flow with no vortices to a flow with two counter-rotating vortices, caused by a transition in the number and location of topological defects in the flow field. Finally, comparing the theoretical predictions to quantitative measurements of both tissue flows and shape during zebrafish body axis elongation, we show that the observed morphogenetic events can be explained by the existence of a fluid-to-solid tissue transition along the anteroposterior axis. These results highlight the role of spatiotemporally-controlled fluid-to-solid transitions in the tissue state as a physical mechanism of embryonic morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.