Evidence map›Paper›PMID 33883283›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Platinum(II)

Pui-Ki Wan, Ka-Chung Tong, Chun-Nam Lok, Chunlei Zhang, Xiao-Yong Chang, Kong-Hung Sze, Alice Sze Tsai Wong, Chi-Ming Che

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Supramolecular platinum complexes for cancer therapy.Current opinion in chemical biology · 2023
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Pui-Ki WanState Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Hong Kong, China.
Ka-Chung TongState Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Hong Kong, China.
Chun-Nam LokState Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Hong Kong, China.
Chunlei ZhangState Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Hong Kong, China.ORCID 0000-0002-7781-0218
Xiao-Yong ChangDepartment of Chemistry, Southern University of Science and Technology of China, Shenzhen, Guangdong 518055, China.
Kong-Hung SzeDepartment of Microbiology, The University of Hong Kong, Hong Kong, China.
Alice Sze Tsai WongSchool of Biological Sciences, The University of Hong Kong, Hong Kong, China.ORCID 0000-0002-0676-6475
Chi-Ming CheState Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Hong Kong, China; cmche@hku.hk.ORCID 0000-0002-2554-7219
State Key Laboratory of Synthetic Chemistry · CNUniversity of Hong Kong · HKSouthern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vimentin is a cytoskeletal intermediate filament protein that plays pivotal roles in tumor initiation, progression, and metastasis, and its overexpression in aggressive cancers predicted poor prognosis. Herein described is a highly effective antitumor and antimetastatic metal complex [Pt

Indexed as

AnimalsAntineoplastic AgentsFemaleHCT116 CellsHumansLung NeoplasmsMiceMice, NudeMolecular Dynamics SimulationOrganoplatinum CompoundsRatsVimentinXenograft Model Antitumor AssaysAntineoplastic AgentsOrganoplatinum CompoundsPt-NHC complexVimentinantimetastasismetabolismN-heterocyclic carbeneplatinumvimentin

Identifiers

PMID33883283
PMCPMC8092596
OpenAlexW3156030967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.