Evidence map›Paper›PMID 33883277›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis.

Saravanapriah Nadarajan, Elisabeth Altendorfer, Takamune T Saito, Marina Martinez-Garcia, Monica P Colaiácovo

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Saravanapriah NadarajanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-5273-4514
Elisabeth AltendorferDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-9621-1632
Takamune T SaitoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4447-4115
Marina Martinez-GarciaDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0001-8491-2557
Monica P ColaiácovoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115 mcolaiacovo@genetics.med.harvard.edu.
Harvard University · US

Funding

Synaptonemal Complex Assembly and Function in MeiosisR01GM072551 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Monica P Colaiacovo · 2005 to 2026
$7.5M
NIGMS NIH HHS R01 GM072551
6 · The paper itself

Abstract

The position of recombination events established along chromosomes in early prophase I and the chromosome remodeling that takes place in late prophase I are intrinsically linked steps of meiosis that need to be tightly regulated to ensure accurate chromosome segregation and haploid gamete formation. Here, we show that RAD-51 foci, which form at the sites of programmed meiotic DNA double-strand breaks (DSBs), exhibit a biased distribution toward off-centered positions along the chromosomes in wild-type

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell CycleCell Cycle ProteinsChromosomesChromosome SegregationCrossing Over, GeneticDNA Breaks, Double-StrandedDNA RepairMeiosisRad51 RecombinaseRecombination, GeneticCaenorhabditis elegans ProteinsCell Cycle ProteinsHIM-17 protein, C elegansrad-51 protein, C elegansRad51 RecombinasecrossoversDNA double-strand breaksHIM-17late prophase I remodelingmeiosis

Identifiers

PMID33883277
PMCPMC8092412
OpenAlexW3153899097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.