ArticleProceedings of the National Academy of Sciences of the United States of America2021
Engineering autoreactive T and B cell responses toward active immunotherapy for inflammatory diseases.
Jason Y H Chang, Darrell J Irvine
Open access · hybridAbstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
2 authors at 2 institutions in 1 country.
Jason Y H ChangKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-2238-8232 Darrell J IrvineKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; djirvine@mit.edu.
Howard Hughes Medical Institute · USMassachusetts Institute of Technology · US
Funding
Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6MVirology and ImmunologyP01AI048240 · NIAID · UNIVERSITY OF WASHINGTON · PI RUPRECHT, RUTH MARGRIT · 2000 to 2020
$46.7MTargeting Immunogenicity to the MPER Hinge and C-helix for BNAb ElicitationP01AI126901 · NIAID · DANA-FARBER CANCER INST · PI IRVINE, DARRELL J · 2016 to 2020
$9.2MMaximizing germinal centers and somatic hypermutation to HIV Env immunogensR37AI125068 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Shane P Crotty, Darrell J Irvine · 2021 to 2026
$5.4MMaximizing germinal centers and somatic hypermutation to HIV Env immunogensR01AI125068 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P, IRVINE, DARRELL J · 2016 to 2020
$4.3MSynthetic biology-regulated RNA vaccinesR01EB025854 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IRVINE, DARRELL J, WEISS, RON · 2018 to 2021
$2.8MImmune engineering of optimized sequential immunization strategies for HIV vaccinesR61AI161297 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CROTTY, SHANE P, IRVINE, DARRELL J · 2021 to 2023
$2.3MNIAID NIH HHS P01 AI048240NIAID NIH HHS P01 AI126901NIAID NIH HHS R01 AI125068NIAID NIH HHS R37 AI125068NIAID NIH HHS R61 AI161297NIAID NIH HHS UM1 AI144462NIBIB NIH HHS R01 EB025854
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Indexed as
B-LymphocytesComplement C3bHumansImmunotherapy, ActiveInflammationLymphocyte ActivationNanofibersPeptide FragmentsT-LymphocytesTumor Necrosis Factor-alphaComplement C3bcomplement C3d,gPeptide FragmentsTumor Necrosis Factor-alpha
Identifiers
PMID33883270
PMCPMC8157984
OpenAlexW3154448038
What OpenQuestion holds
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LicenceCC BY
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