ArticlemSphere2021
Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts.
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Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13citing papers in PubMed, 1 pooled it
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antibody tests for identification of current and past infection with SARS-CoV-2.The Cochrane database of systematic reviews · 2022Pooled it
- Acute respiratory infection (COVID-19) risk prediction in travelers: A random forest model.Infectious Disease Modelling · 2026Article
- Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production.Communications biology · 2024Article
- Article
- Detection of COVID-19-related biomarkers by electrochemical biosensors and potential for diagnosis, prognosis, and prediction of the course of the disease in the context of personalized medicine.Analytical and bioanalytical chemistry · 2023Review
- SARS-CoV-2 multi-antigen protein microarray for detailed characterization of antibody responses in COVID-19 patients.PloS one · 2023Article
- An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force.Biosensors & bioelectronics · 2022Article
- Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes.PLoS computational biology · 2022Article
- Point-of-Care Testing-The Key in the Battle against SARS-CoV-2 Pandemic.Micromachines · 2021Review
- Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.ACS omega · 2021Article
- Evaluation and Comparison of Serological Methods for COVID-19 Diagnosis.Frontiers in molecular biosciences · 2021Review
- Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC.medRxiv : the preprint server for health sciences · 2020Article
- Mater Artium Necessitas: The Birth of a COVID-19 Command Center.Academic pathologyArticle
Corrections and comments
- Update of
Authors and funding
41 authors.
Robert H Bortz *Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Catalina Florez *Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Ethan Laudermilch *Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Ariel S Wirchnianski *Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Gorka LassoDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Ryan J MalonisDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
George I GeorgievDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Olivia VergnolleDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Natalia G HerreraDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Nicholas C MoranoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Sean T CampbellDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Erika P OrnerDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Amanda MengottoDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
M Eugenia DieterleDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
J Maximilian FelsDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Denise HaslwanterDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Rohit K JangraDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-3119-0869
Alev CelikgilDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Duncan KimmelDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
James H LeeDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Margarette C MarianoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Antonio NakouziDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Jose QuirozDivision of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
Johanna RiveraDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Wendy A SzymczakDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0002-0747-1169
Karen TongDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Jason BarnhillDepartment of Chemistry and Life Science, United States Military Academy at West Point, West Point, New York, USA.
Mattias N E ForsellDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.ORCID 0000-0001-6904-742X
Clas AhlmDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Daniel T SteinMontefiore Medical Center, Bronx, New York, USA.
Liise-Anne PirofskiDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
D Yitzchak GoldsteinDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Scott J GarforthDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Steven C AlmoDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Johanna P DailyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Michael B PrystowskyDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
James D FaixDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Amy S FoxDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Louis M WeissDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA louis.weiss@einsteinmed.org jon.lai@einsteinmed.org kartik.chandran@einsteinmed.org.ORCID 0000-0002-0357-7396
Jonathan R LaiDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA louis.weiss@einsteinmed.org jon.lai@einsteinmed.org kartik.chandran@einsteinmed.org.
Kartik ChandranDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA louis.weiss@einsteinmed.org jon.lai@einsteinmed.org kartik.chandran@einsteinmed.org.ORCID 0000-0003-0232-7077
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6MPatient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Kathryn M. Anastos · 2017 to 2026
$28.3MCTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7MMicrosporidia: invasion apparatusR01AI124753 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2016 to 2025
$4.2MNovel Biologics Designed to Mobilize HIV-specific CTL for Sustained HIV RemissionR01AI145024 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI ALMO, STEVEN C., GOLDSTEIN, HARRIS · 2019 to 2023
$4.1MDissecting the receptor-mediated infection mechanisms of hantavirusesR01AI132633 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CHANDRAN, KARTIK · 2017 to 2021
$3.2MEngineered, multispecific antibodies as broad anti-filovirus therapeuticsR01AI125462 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI LAI, JONATHAN R. · 2017 to 2020
$3.0MCovid-19-related cervical cancer treatment interruption and role of neoadjuvant chemotherapyR01CA236546 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI DRYDEN-PETERSON, SCOTT · 2019 to 2023
$2.5MComposition and formation of the cyst wallR01AI134753 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2018 to 2022
$2.1MMolecular mechanisms of resistance to HER2 inhibitors in breast cancerK08CA143153 · NCI · VANDERBILT UNIVERSITY · PI REXER, BRENT N · 2010 to 2014
$815kDiscovery & characterization of human monoclonal antibodies targeting multiple arthritogenic alphavirusesF30AI150055 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MALONIS, RYAN J · 2020 to 2022
$150kNCATS NIH HHS UL1 TR002556NCI NIH HHS K08 CA143153NCI NIH HHS R01 CA236546NIAID NIH HHS AI13261NIAID NIH HHS F30 AI150055NIAID NIH HHS P30 AI124414NIAID NIH HHS R01 AI124753NIAID NIH HHS R01 AI125462NIAID NIH HHS R01 AI132633NIAID NIH HHS R01 AI134753NIAID NIH HHS R01 AI145024NIGMS NIH HHS 2T32GM007288-45NIGMS NIH HHS T32 GM007288
Abstract
The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to place an immense burden on societies and health care systems. A key component of COVID-19 control efforts is serological testing to determine the community prevalence of SARS-CoV-2 exposure and quantify individual immune responses to prior SARS-CoV-2 infection or vaccination. Here, we describe a laboratory-developed antibody test that uses readily available research-grade reagents to detect SARS-CoV-2 exposure in patient blood samples with high sensitivity and specificity. We further show that this sensitive test affords the estimation of viral spike-specific IgG titers from a single sample measurement, thereby providing a simple and scalable method to measure the strength of an individual's immune response. The accuracy, adaptability, and cost-effectiveness of this test make it an excellent option for clinical deployment in the ongoing COVID-19 pandemic.
Indexed as
AdolescentAdultAgedAntibodies, ViralAntibody SpecificityCase-Control StudiesCohort StudiesCOVID-19COVID-19 Serological TestingEnzyme-Linked Immunosorbent AssayEpidemiological MonitoringFemaleHumansImmunoglobulin AImmunoglobulin GMaleAntibodies, ViralImmunoglobulin AImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19IgAIgGlaboratory diagnostic testquantitative testSARS-CoV-2serologyspike protein
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.