Evidence map›Paper›PMID 33883238›Full record

ArticleNeurology2021

Accuracy of Cardiac Innervation Scintigraphy for Mild Cognitive Impairment With Lewy Bodies.

Gemma Roberts, Rory Durcan, Paul C Donaghy, Sarah Lawley, Joanna Ciafone, Calum A Hamilton, Sean J Colloby, Michael J Firbank, Louise Allan, Nicola Barnett and 8 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. [PCN reports : psychiatry and clinical neurosciences · 2025
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  11. Delirium-onset prodromal Lewy body disease: A series of 5 cases.Clinical parkinsonism & related disorders · 2024
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  15. [The clinical value ofSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023
    Review
  16. Article
  17. Optimal Protocol and Clinical Usefulness ofNuclear medicine and molecular imaging · 2023
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  18. Article
  19. Article
  20. A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 3 countries.

Gemma RobertsFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK. Gemma.roberts@newcastle.ac.uk.ORCID 0000-0002-6445-4023
Rory DurcanFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Paul C DonaghyFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Sarah LawleyFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Joanna CiafoneFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Calum A HamiltonFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.ORCID 0000-0002-9812-3150
Sean J CollobyFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Michael J FirbankFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.ORCID 0000-0002-9536-0185
Louise AllanFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.ORCID 0000-0002-8912-4901
Nicola BarnettFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Sally BarkerFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Kim HoweFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Tamir AliFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
George S PetridesFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Jim LloydFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
John-Paul TaylorFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
John O'BrienFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Alan J ThomasFrom the Translational and Clinical Research Institute (G.R., R.D., P.C.D., S.L., J.C., C.A.H., S.J.C., M.J.F., N.B., S.B., J.L., J.-P.T., A.J.T.), Newcastle University; Nuclear Medicine Department (G.R., K.H., T.A., G.S.P., J.L.), Royal Victoria Infirmary, Newcastle upon Tyne; University of Exeter Medical School (L.A.); and Department of Psychiatry (J.O.), University of Cambridge School of Clinical Medicine, UK.
Royal Victoria Infirmary · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo provide evidence that cardiac I-123-metaiodobenzylguanidine sympathetic innervation imaging (MIBG) scintigraphy differentiates probable mild cognitive impairment with Lewy bodies (MCI-LB) from mild cognitive impairment due to Alzheimer disease (MCI-AD), we scanned patients with MCI and obtained consensus clinical diagnoses of their MCI subtype. We also performed baseline FP-CIT scans to compare the accuracy of MIBG and FP-CIT.

methodsWe conducted a prospective cohort study into the accuracy of cardiac MIBG scintigraphy in the diagnosis of MCI-LB. Follow-up clinical assessment was used to diagnose MCI-AD (no core features of MCI-LB and normal FP-CIT), probable MCI-LB (2 or more core features, or 1 core feature with abnormal FP-CIT), or possible MCI-LB (1 core feature or abnormal FP-CIT). For the comparison between MIBG and FP-CIT, only core clinical features were used for diagnosis.

resultsWe recruited 95 people with mild cognitive impairment. Cardiac MIBG was abnormal in 22/37 probable and 2/15 possible MCI-LB cases and normal in 38/43 MCI-AD cases. The sensitivity in probable MCI-LB was 59% (95% confidence interval [CI], 42%-75%), specificity 88% (75%-96%), and accuracy 75% (64%-84%). The positive likelihood ratio was 5.1 and negative likelihood ratio 0.46. With symptom-only diagnoses, the accuracies were 79% for MIBG (95% CI, 68%-87%) and 76% for FP-CIT (95% CI, 65%-85%).

conclusionsCardiac MIBG appears useful in early disease, with an abnormal scan highly suggestive of MCI-LB. Validation in a multicenter setting is justified. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that cardiac MIBG distinguishes MCI-LB from MCI-AD.

Indexed as

3-IodobenzylguanidineAgedAged, 80 and overAlzheimer DiseaseCognitive DysfunctionDiagnosis, DifferentialFemaleFollow-Up StudiesHeartHumansLewy Body DiseaseMaleMyocardial Perfusion ImagingSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane3-IodobenzylguanidineTropanes

Identifiers

PMID33883238
PMCPMC8205462
OpenAlexW3154164963

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.