Evidence map›Paper›PMID 33883206›Full record

ArticleEuropean journal of hospital pharmacy : science and practice2022

Administration of benralizumab in a patient with severe asthma admitted to the intensive care unit with COVID-19 pneumonia: case report.

Johannes Anthon Kroes, Sander Wilhelm Zielhuis, Carina Bethlehem, Anneke Ten Brinke, Eric Nico Van Roon

Open access · hybridAbstract readCase Reports
In one paragraph

Article in European journal of hospital pharmacy : science and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Johannes Anthon KroesDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands j.a.kroes@rug.nl.ORCID 0000-0002-9418-4861
Sander Wilhelm ZielhuisDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
Carina BethlehemDepartment of Intensive Care, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
Anneke Ten BrinkeDepartment of Pulmonary Diseases, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
Eric Nico Van RoonDepartment of Clinical Pharmacy and Pharmacology, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.
Medisch Centrum Leeuwarden · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A patient with severe asthma on benralizumab therapy was admitted to the intensive care unit (ICU) for a coronavirus disease 2019 (COVID-19) infection. At the end of the 8 week benralizumab dosing interval, discussion arose as to whether benralizumab should be administered or if treatment should be discontinued, due to the lack of experience with benralizumab in this situation. Severe broncho-obstruction developed, and the next injection of benralizumab was administered during ICU admission without detrimental symptoms. With this case report, we would like to share our experience with the safe administration of benralizumab during COVID-19 pneumonia, guiding doctors in future decision making.

Indexed as

Anti-Asthmatic AgentsAsthmaCOVID-19 Drug TreatmentAntibodies, Monoclonal, HumanizedHumansIntensive Care UnitsAnti-Asthmatic AgentsAntibodies, Monoclonal, Humanizedbenralizumabcase reportsCOVID-19critical carepulmonary medicinesafety

Identifiers

PMID33883206
PMCPMC9251165
OpenAlexW3154904957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.