Evidence map›Paper›PMID 33883183›Full record

ArticleJournal of clinical microbiology2021

Structural, Genetic, and Serological Elucidation of Streptococcus pneumoniae Serogroup 24 Serotypes: Discovery of a New Serotype, 24C, with a Variable Capsule Structure.

Feroze Ganaie, Karsten Maruhn, Chengxin Li, Richard J Porambo, Pernille L Elverdal, Chitrananda Abeygunwardana, Mark van der Linden, Jens Ø Duus, Carmen L Sheppard, Moon H Nahm

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pneumococcal Vaccine for Adults Aged ≥19 Years: Recommendations of the Advisory Committee on Immunization Practices, United States, 2023.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2023
    Guideline
  3. Pooled it
  4. Article
  5. Accurate serotype identification ofJournal of clinical microbiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Review
  15. Article
  16. Comparative Genotyping of Malaysian Clinical Isolates ofThe Malaysian journal of medical sciences : MJMS · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Genome sequences of 36Microbiology resource announcements · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Feroze Ganaie *Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Karsten Maruhn *National Reference Center for Streptococci, University Hospital RWTH, Aachen, Germany.
Chengxin Li *Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.
Richard J PoramboMerck & Co., Inc., West Point, Pennsylvania, USA.
Pernille L ElverdalSSI Diagnostica A/S, Research & Development, Hillerød, Denmark.
Chitrananda AbeygunwardanaMerck & Co., Inc., West Point, Pennsylvania, USA.
Mark van der LindenNational Reference Center for Streptococci, University Hospital RWTH, Aachen, Germany.
Jens Ø DuusDepartment of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark.
Carmen L SheppardVaccine Preventable Bacteria Section, Public Health England-National Infection Service, Colindale, London, United Kingdom.
Moon H NahmDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
RWTH Aachen University · DETechnical University of Denmark · DKUnited States Military Academy · USUniversity of Alabama at Birmingham · USPublic Health England · GB

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Acquired deficiency of innate immunity (ficolin-2) among elderly adultsR01AG050607 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAHM, MOON H. · 2015 to 2019
$1.6M
MicroCal Auto-iTC200; automated high sensitivity isothermal titration calorimetryS10RR026478 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROUILLETTE, CHRISTIE G. · 2010 to 2010
$250k
NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR026478NIA NIH HHS R01 AG050607
6 · The paper itself

Abstract

Pneumococcal capsules are important in pneumococcal pathogenesis and vaccine development. Although conjugate vaccines have brought about a significant reduction in invasive pneumococcal disease (IPD) caused by vaccine serotypes, the relative serotype prevalence has shifted with the dramatic emergence of serotype 24F in some countries. Here, we describe 14 isolates (13 IPD and 1 non-IPD) expressing a new capsule type, 24C, which resembles 24F but has a novel serological profile. We also describe the antigenic, biochemical, and genetic basis of 24F and 24C and the related serotypes 24A and 24B. Structural studies show that 24B, 24C, and 24F have identical polysaccharide backbones [β-Rib

Indexed as

Pneumococcal InfectionsStreptococcus pneumoniaeHumansPneumococcal VaccinesSerogroupVaccines, ConjugatePneumococcal VaccinesVaccines, Conjugatecapsule polysaccharidegenetic heterogeneityserogroupStreptococcus pneumoniaevaccine

Identifiers

PMID33883183
PMCPMC8218768
OpenAlexW3154953303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.