Evidence map›Paper›PMID 33883015›Full record

ArticleJournal of medical case reports2021

Multisite transcranial direct current stimulation associated with cognitive training in episodic memory and executive functions in individuals with Alzheimer's disease: a case report.

Letícia Zanetti Marchi, Rayssa Gabriela Dantas Ferreira, Gabriella Nayara Siqueira de Lima, Jessyca Alves Silvestre da Silva, Daniel Marinho Cezar da Cruz, Bernardino Fernandez-Calvo, Suellen Mary Marinho Dos Santos Andrade

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02772185 (Neurostimulation and Cognitive Intervention in Alzheimer's Disease), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02772185 phase2 / phase3unknown statusnot on this map

Neurostimulation and Cognitive Intervention in Alzheimer's Disease

TypeinterventionalSponsorFederal University of ParaíbaRan2016 to 2019Enrolled60ConditionsAlzheimer's DiseaseArmsactive tDCS, sham tDCS, real CT, placebo CT
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Letícia Zanetti MarchiDepartment of Occupational Therapy, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, Brazil. leticiamarchi@gmail.com.ORCID http://orcid.org/0000-0003-3802-8749
Rayssa Gabriela Dantas FerreiraDepartment of Occupational Therapy, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, Brazil.
Gabriella Nayara Siqueira de LimaDepartment of Occupational Therapy, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, Brazil.
Jessyca Alves Silvestre da SilvaDepartment of Occupational Therapy, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, Brazil.
Daniel Marinho Cezar da CruzDepartment of Occupational Therapy and PostGraduate Program in Occupational Therapy, Universidade Federal de São Carlos, Rod. Washington Luís km 235-SP-310, São Carlos, SP, CEP 13565-905, Brazil.
Bernardino Fernandez-CalvoPostgraduate Program in Cognitive Neuroscience and Behavior, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, Brazil.
Suellen Mary Marinho Dos Santos AndradePostgraduate Program in Cognitive Neuroscience and Behavior, Universidade Federal da Paraíba, Campus I, Cidade Universitária, João Pessoa, PB, CEP: 58051-900, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDementia is among the most common chronic noncommunicable neurodegenerative diseases. In the long term, it causes disability and loss of autonomy and independence. It is estimated that there are 35.6 million people with Alzheimer's disease worldwide. Several clinical aspects of this disease have been widely studied, but the main focus of study has been memory loss, which is one of the first symptoms. The present study proposes an innovative intervention that combines cognitive training and multisite transcranial direct current stimulation, which interferes with other clinical aspects of the subject. CASE PRESENTATION: In this study, we present two subjects diagnosed with mild Alzheimer's disease. Subject 1 is an 82-year-old Brazilian Latin American woman with a high school education who was diagnosed with Alzheimer's disease 8 years ago and uses an Exelon patch. Subject 2 is an 88-year-old Brazilian Latin American woman with an incomplete primary education who was diagnosed with Alzheimer's disease 1 year ago and received medical orientation to temporarily discontinue medications for Alzheimer's disease. Both participants were subjected to intermittent cognitive training sessions and concomitant transcranial stimulation in three weekly 30-minute sessions in which a brain area was stimulated every 10 minutes for a total of 24 sessions, with a 2-month follow-up. Transcranial stimulation was applied to six different regions of the cortex: the dorsolateral prefrontal cortex bilaterally, the somatosensory association cortex bilaterally and Broca's and Wernicke's areas. Comparing the results of tests performed before and after the treatment period, a 1-point improvement was observed for both subjects on the Word Recall task of the Alzheimer Disease Assessment Scale, which evaluates symptoms related to the decline of episodic memory. Improvement in the executive functions domain was also observed through the results of the Stroop test, Victoria version.

conclusionsThe results from the two presented cases show that multisite transcranial stimulation associated with cognitive training is an effective adjuvant method for the treatment of patients diagnosed with mild Alzheimer's disease. Its effects can benefit patients' daily routines by reducing cognitive deficits by keeping intact areas active and/or compensating for lost functions. Trial registration NCT02772185. Registered 13 May 2016, http://www.clinicaltrials.gov/ct2/show/NCT02772185 . Retrospectively registered.

Indexed as

Memory, EpisodicTranscranial Direct Current StimulationAged, 80 and overAlzheimer DiseaseBrazilCognitionExecutive FunctionFemaleHumansMemoryTreatment OutcomeAlzheimer’s diseaseCase reportCognitive trainingEpisodic memoryExecutive functionsMultisite transcranial direct current stimulation

Identifiers

PMID33883015
PMCPMC8061233

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.