ArticleBMC genomics2021
Dynamics of rumen gene expression, microbiome colonization, and their interplay in goats.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Multi-omic analysis reveals that theAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Bidirectional regulation of gut microbiota and young ruminant host: implications for intestinal development and mucosal immunity.Journal of animal science and biotechnology · 2026Review
- Review
- Microbiome-host co-oscillation patterns in shaping ruminal ecosystem from birth to puberty in a goat model.Science China. Life sciences · 2026Article
- Green forage impacts on the DNA methylation in the ruminal wall of Italian mediterranean dairy buffaloes.Scientific reports · 2025Article
- Maternal Roughage Sources Influence the Gastrointestinal Development of Goat Kids by Modulating the Colonization of Gastrointestinal Microbiota.Animals : an open access journal from MDPI · 2025Article
- Transcriptomic characterization of the functional and morphological development of the rumen wall in weaned lambs fed a diet containing yeast co-cultures ofFrontiers in veterinary science · 2025Article
- Yaks Are Dependent on Gut Microbiota for Survival in the Environment of the Qinghai Tibet Plateau.Microorganisms · 2024Review
- Microbial Metagenomes and Host Transcriptomes Reveal the Dynamic Changes of Rumen Gene Expression, Microbial Colonization and Co-Regulation of Mineral Element Metabolism in Yaks from Birth to Adulthood.Animals : an open access journal from MDPI · 2024Article
- Postnatal Growth and Development of the Rumen: Integrating Physiological and Molecular Insights.Biology · 2024Review
- Coping with extremes: the rumen transcriptome and microbiome co-regulate plateau adaptability of Xizang goat.BMC genomics · 2024Article
- Metagenomics reveals the temporal dynamics of the rumen resistome and microbiome in goat kids.Microbiome · 2024Article
- Heritability estimates and genome-wide association study of methane emission traits in Nellore cattle.Journal of animal science · 2024Article
- Exploring the additive effect of Ampelopsis grossedentata flavonoids and Tween 80 on feeding Nubian goats.Frontiers in veterinary science · 2024Article
- The early life immune dynamics and cellular drivers at single-cell resolution in lamb forestomachs and abomasum.Journal of animal science and biotechnology · 2023Article
- Effects of fermented herbal tea residue on meat quality, rumen fermentation parameters and microbes of black goats.AMB Express · 2023Article
- Single-cell transcriptome and metagenome profiling reveals the genetic basis of rumen functions and convergent developmental patterns in ruminants.Genome research · 2023Article
- Physical, Metabolic, and Microbial Rumen Development in Goat Kids: A Review on the Challenges and Strategies of Early Weaning.Animals : an open access journal from MDPI · 2023Review
- The Colonization of Rumen Microbiota and Intervention in Pre-Weaned Ruminants.Animals : an open access journal from MDPI · 2023Review
- Absence of microbiome triggers extensive changes in the transcriptional profile of Hermetia illucens during larval ontology.Scientific reports · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPreweaned rumen development is vital for animal health and efficient fermentation. In this study, we integrated ruminal transcriptomic and metagenomic data to explore the dynamics of rumen functions, microbial colonization, and their functional interactions during the first 8 weeks of life in goats.
resultsThe dynamic rumen transcriptomic and microbial profiles both exhibited two distinct phases during early rumen development. The differentially expressed genes of the rumen transcriptome between the two phases showed that the immune-related response was enriched in the first phase and nutrient-related metabolism was enriched in the second phase, whereas the differentially expressed genes of the rumen microbiome were enriched in bacteriocin biosynthesis and glycolysis/gluconeogenesis activities. The developmental shift in the rumen transcriptome (at d 21) was earlier than the feed stimulus (at d 25) and the shift in the rumen microbiome (at d 42). Additionally, 15 temporal dynamic rumen gene modules and 20 microbial modules were revealed by coexpression network analysis. Functional correlations between the rumen and its microbiome were primarily involved in rumen pH homeostasis, nitrogen metabolism and the immune response. Rumen gene modules associated with the microbial alpha diversity index were also enriched in the immune response process.
conclusionsThe present study touched the critical developmental process of rumen functions, microbial colonization and their functional interactions during preweaned development. Taken together, these results demonstrated that rumen development at the first phase is more likely a programmed process rather than stimulation from feed and the microbiome, while the shift of rumen metagenomes was likely regulated by both the diet and host. The intensive functional correlations between rumen genes and the microbiome demonstrated that synergistic processes occurred between them during early rumen development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.