Evidence map›Paper›PMID 33882718›Full record

ArticleTissue engineering. Part A2021

Regional Gene Therapy with Transduced Human Cells: The Influence of "Cell Dose" on Bone Repair.

Hansel Ihn, Hyunwoo Kang, Brenda Iglesias, Osamu Sugiyama, Amy Tang, Roger Hollis, Sofia Bougioukli, Tautis Skorka, Sanghyun Park, Donald Longjohn and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  4. Bioengineering (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Hansel IhnDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-1262-8535
Hyunwoo KangDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Brenda IglesiasDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Osamu SugiyamaDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Amy TangDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Roger HollisDepartment of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA.
Sofia BougioukliDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Tautis SkorkaUSC Molecular Imaging Center, Los Angeles, California, USA.
Sanghyun ParkOrthopaedic Institute for Children, J. Vernon Luck. Sr., Orthopedic Research Center, Los Angeles, California, USA.
Donald LongjohnDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Daniel A OakesDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
Donald B KohnDepartment of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA.
Jay R LiebermanDepartment of Orthopedic Surgery, University of Southern California, Los Angeles, California, USA.
University of Southern California · USUniversity of California, Los Angeles · USLAC+USC Medical Center · USOrthopaedic Institute for Children · US

Funding

The Use of Regional Gene Delivery to Heal Critical Sized Bone DefectsR01AR057076 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIEBERMAN, JAY R. · 2010 to 2021
$3.9M
NIAMS NIH HHS R01 AR057076
6 · The paper itself

Abstract

Regional gene therapy using a lentiviral vector containing the

Indexed as

Genetic TherapyAnimalsHumansRatsX-Ray MicrotomographyBMP-2critical bone defectgene therapylentiviral vectornonunion

Identifiers

PMID33882718
PMCPMC8827114
OpenAlexW3154587908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.