Evidence map›Paper›PMID 33882688›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages.

Vishal Kothari, Jingjing Tang, Yi He, Farah Kramer, Jenny E Kanter, Karin E Bornfeldt

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Remnant Lipoprotein Hypothesis of Diabetes-Associated Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 5 countries.

Vishal KothariDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., J.T., Y.H., F.K., J.E.K., K.E.B.).
Jingjing TangDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., J.T., Y.H., F.K., J.E.K., K.E.B.).
Yi HeDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., J.T., Y.H., F.K., J.E.K., K.E.B.).
Farah KramerDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., J.T., Y.H., F.K., J.E.K., K.E.B.).
Jenny E KanterDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., J.T., Y.H., F.K., J.E.K., K.E.B.).
Karin E BornfeldtDepartment of Medicine, Division of Metabolism, Endocrinology and Nutrition, UW Medicine Diabetes Institute (V.K., J.T., Y.H., F.K., J.E.K., K.E.B.).
Diabetes Australia · AUUniversity of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Role of Serum Amyloid A in Diabetic Vascular DiseaseP01HL092969 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E. · 2008 to 2019
$23.5M
Triglycerides, Diabetes and Cardiovascular DiseaseP01HL151328 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 2020 to 2026
$19.6M
Identifying new strategies for prevention of cardiovascular complications of diabetesR35HL150754 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E · 2020 to 2025
$6.2M
Structural basis for cardioprotective HDLR01HL149685 · NHLBI · UNIVERSITY OF WASHINGTON · PI BORNFELDT, KARIN E., HEINECKE, JAY W · 2020 to 2023
$2.8M
NHLBI NIH HHS P01 HL092969NHLBI NIH HHS P01 HL151328NHLBI NIH HHS R01 HL149685NHLBI NIH HHS R35 HL150754NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

ADAM17 ProteinAnimalsApolipoprotein A-IATP Binding Cassette Transporter 1Cells, CulturedChemokine CCL2Chemokine CXCL1CholesterolCholesterol, HDLFemaleInflammationInflammation MediatorsInterleukin-1betaLipoproteins, HDLMacrophages, PeritonealMaleAbca1 protein, mouseADAM17 ProteinAdam17 protein, mouseAPOA1 protein, humanApolipoprotein A-IATP Binding Cassette Transporter 1Ccl2 protein, mouseChemokine CCL2Chemokine CXCL1CholesterolCholesterol, HDLCxcl1 protein, mouseIL1B protein, mouseInflammation MediatorsInterleukin-1betaLipoproteins, HDLReceptors, LDLTnf protein, mouseTumor Necrosis Factor-alphaADAM17 proteincholesterolHDLinflammationlipoproteinsmacrophages

Identifiers

PMID33882688
PMCPMC8159900
OpenAlexW3156960706

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.