ArticleYearbook of medical informatics2021
Drawing Reproducible Conclusions from Observational Clinical Data with OHDSI.
Article in Yearbook of medical informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Methylphenidate and Long-Term Risk of Cardiovascular Diseases: A Nationwide Cohort Study.Pharmacoepidemiology and drug safety · 2026Article
- Real-World Use of Controlled Terminologies, Ontologies, and Vocabularies for Evidence Generation Across a Large International Observational Network: Challenges and Lessons Learned From a Mixed Method Study.JMIR medical informatics · 2026Article
- A comparison of Fast Healthcare Interoperability Resources and Observational Medical Mutcomes Partnership electronic health record data within the All of Us Research Program.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Emerging role of artificial intelligence in necrotizing enterocolitis and implementation challenges.Pediatric research · 2026Review
- From study design to executable code: automating target trial emulation with large language models.JAMIA open · 2026Article
- Assessment of real-world evidence research competencies in federated research networks: a maternal health fellowship program evaluation.JAMIA open · 2026Article
- Federated learning's uncomfortable truth: why human networks matter more than neural networks.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- AI-driven quality enhancement of medical datasets: a closed-loop framework of synthesis, annotation, quality control, and integration.Frontiers in medicine · 2026Review
- Assessing Covariate Balance With Small Sample Sizes.Statistics in medicine · 2025Article
- Assessing Covariate Balance with Small Sample Sizes.medRxiv : the preprint server for health sciences · 2025Article
- Breaking Digital Health Barriers Through a Large Language Model-Based Tool for Automated Observational Medical Outcomes Partnership Mapping: Development and Validation Study.Journal of medical Internet research · 2025Article
- Disparities in Time to Diagnosis of Radiographic Axial Spondyloarthritis.The Journal of rheumatology · 2025Observational
- Reductions in Blood Lead Level Screening During Peak COVID-19 Restrictions and Beyond.Public health challenges · 2025Article
- Endometriosis and autoimmunity: a large-scale case-control study of endometriosis and 10 distinct autoimmune diseases.npj women's health · 2025Article
- Sharing sensitive data in life sciences: an overview of centralized and federated approaches.Briefings in bioinformatics · 2024Review
- Comparative safety and effectiveness of angiotensin converting enzyme inhibitors and thiazides and thiazide-like diuretics under strict monotherapy.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Automating assignment of HIV+ patients into phenogroups from demography bound phenotype attack rates.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- Using National COVID cohort collaborative (N3C) data to explore impact of COVID-19 infection on kidney function in patients receiving lithium therapy.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2024Article
- The Stanford Medicine data science ecosystem for clinical and translational research.JAMIA open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveThe current observational research literature shows extensive publication bias and contradiction. The Observational Health Data Sciences and Informatics (OHDSI) initiative seeks to improve research reproducibility through open science.
methodsOHDSI has created an international federated data source of electronic health records and administrative claims that covers nearly 10% of the world's population. Using a common data model with a practical schema and extensive vocabulary mappings, data from around the world follow the identical format. OHDSI's research methods emphasize reproducibility, with a large-scale approach to addressing confounding using propensity score adjustment with extensive diagnostics; negative and positive control hypotheses to test for residual systematic error; a variety of data sources to assess consistency and generalizability; a completely open approach including protocol, software, models, parameters, and raw results so that studies can be externally verified; and the study of many hypotheses in parallel so that the operating characteristics of the methods can be assessed.
resultsOHDSI has already produced findings in areas like hypertension treatment that are being incorporated into practice, and it has produced rigorous studies of COVID-19 that have aided government agencies in their treatment decisions, that have characterized the disease extensively, that have estimated the comparative effects of treatments, and that the predict likelihood of advancing to serious complications.
conclusionsOHDSI practices open science and incorporates a series of methods to address reproducibility. It has produced important results in several areas, including hypertension therapy and COVID-19 research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.