Evidence map›Paper›PMID 33882457›Full record

ArticleAging2021

Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer.

Fangbin Zhang, Yan Yan, Xinguang Cao, Jinping Zhang, Yingxia Li, Changqing Guo

Open access · greenAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. The miR-338-5p/METTL3 axis regulates m6A modification to inhibit tumor progression in triple-negative breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. METTL3-mediated NOncogene · 2024
    Article
  7. Review
  8. Review
  9. NJournal of translational internal medicine · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Emerging Regulatory Mechanisms of NPhenomics (Cham, Switzerland) · 2023
    Review
  14. Review
  15. The emerging role of mFrontiers in cell and developmental biology · 2023
    Review
  16. Role of m6A writers, erasers and readers in cancer.Experimental hematology & oncology · 2022
    Review
  17. Multifaceted Roles of theBiomolecules · 2022
    Review
  18. Article
  19. Role of main RNA modifications in cancer: NSignal transduction and targeted therapy · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Fangbin ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Yan YanDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Xinguang CaoDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Jinping ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Yingxia LiDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
Changqing GuoDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unmasking the complex regulatory pathways that mediate the malignant phenotypes of cancer cells can provide novel targets for therapies that could limit the recurrence and metastasis of gastric cancer (GC). Herein, we intended to clarify the role of embryonic ectoderm development protein (EED), microRNA-228-5p (miR-338-5p), methyltransferase like 3 (METTL3) and CUB domain containing protein 1 (CDCP1) in GC. Differentially expressed miRNAs and their target genes were extracted by

Indexed as

Gene Expression Regulation, NeoplasticAdenosineAgedAnimalsAntigens, NeoplasmCell Adhesion MoleculesCell Line, TumorCell MovementCell ProliferationDisease-Free SurvivalFemaleFollow-Up StudiesGastrectomyGene Knockdown TechniquesHumansMaleAdenosineAntigens, NeoplasmCDCP1 protein, humanCell Adhesion MoleculesEED protein, humanMethyltransferasesMETTL3 protein, humanMicroRNAsMIRN338 microRNA, humanN-methyladenosinePolycomb Repressive Complex 2CDCP1EEDmethylationMETTL3microRNA-338-5p

Identifiers

PMID33882457
PMCPMC8109089
OpenAlexW3156925014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.