Evidence map›Paper›PMID 33882456›Full record

ArticleAging2021

Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function.

Peipei Li, Zhuchun Lin, Yachun An, Jing Lin, Aizhen Zhang, Shuangyan Wang, Hailong Tu, Jie Ran, Jinpeng Wang, Yu Liang and 4 more

Open access · greenAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Peipei LiSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Zhuchun LinFirst People's Hospital of Jinan, Jinan 250011, China.
Yachun AnSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Jing LinThe Waksman Institute of Microbiology, Rutgers University, Piscataway, NJ 08854, USA.
Aizhen ZhangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Shuangyan WangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Hailong TuSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Jie RanCollege of Life Sciences, Shandong Normal University, Jinan 250014, China.
Jinpeng WangCollege of Life Sciences, Shandong Normal University, Jinan 250014, China.
Yu LiangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Ziyi LiuSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Chao YeSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Xiaolong FuMOE Key Laboratory for Developmental Genes and Human Disease, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Institute of Life Sciences, Southeast University, Nanjing 210096, China.
Jiangang GaoSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan 250100, China.
Shandong University · CNShandong Normal University · CNJinan City People's Hospital · CNRutgers, The State University of New Jersey · USSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piccolo is a presynaptic protein with high conservation among different species, and the expression of Piccolo is extensive in vertebrates. Recently, a small fragment of Piccolo (Piccolino), arising due to the incomplete splicing of intron 5/6, was found to be present in the synapses of retinas and cochleae. However, the comprehensive function of Piccolo in the retina and cochlea remains unclear. In this study, we generated

Indexed as

AnimalsCytoskeletal ProteinsDisease Models, AnimalFemaleHair Cells, AuditoryHumansIntronsMaleMiceMice, KnockoutNeuropeptidesRetinaRetinitis PigmentosaRNA SplicingSynapsesCytoskeletal ProteinsNeuropeptidesPclo protein, mousecochleaCRISPR/Cas9mousepiccoloretina

Identifiers

PMID33882456
PMCPMC8109093
OpenAlexW3153668823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.