Observational studyArchives of gerontology and geriatrics
The multidimensional prognostic index (MPI) for the prognostic stratification of older inpatients with COVID-19: A multicenter prospective observational cohort study.
Observational study in Archives of gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Multidimensional frailty as a predictor of mortality among older adults: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis.Ageing research reviews · 2021Pooled it
- Sex and the Multidimensional Prognostic Index in 3.5-year post-COVID-19 mortality among older adults: evidence of a time-varying effect.Internal and emergency medicine · 2026Article
- Arm circumference predicts 12-month mortality in older adults with hip fracture.European geriatric medicine · 2026Article
- Impact of multidimensional assessment on anti-fracture treatment decisions in patients with fragility hip fractures within a Fracture Liaison Service.BMC geriatrics · 2025Article
- Review
- The multidimensional prognostic index (MPI) predicts long-term mortality in old type 2 diabetes mellitus patients: a 13-year follow-up study.Journal of endocrinological investigation · 2024Article
- Observational
- Older People Hospitalized for COVID-19: Prognostic Role of Multidimensional Prognostic Index and Other Prognostic Scores.Journal of clinical medicine · 2023Article
- Can the Multidimensional Prognostic Index Improve the Identification of Older Hospitalized Patients with COVID-19 Likely to Benefit from Mechanical Ventilation? An Observational, Prospective, Multicenter Study.Journal of the American Medical Directors Association · 2022Observational
- Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency.Aging clinical and experimental research · 2022Article
- COVID-19, Vulnerability, and Long-Term Mortality in Hospitalized and Nonhospitalized Older Persons.Journal of the American Medical Directors Association · 2022Article
- The AIFELL Score as a Predictor of Coronavirus Disease 2019 (COVID-19) Severity and Progression in Hospitalized Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical Frailty Scale (CFS) indicated frailty is associated with increased in-hospital and 30-day mortality in COVID-19 patients: a systematic review and meta-analysis.Annals of intensive care · 2022Article
- Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis.Annals of translational medicine · 2022Article
- Clinical presentation and outcomes of COVID-19 in older hospitalised patients assessed by the record-based multidimensional prognostic index, a cross-sectional study.European geriatric medicine · 2021Article
- Multidimensional Prognostic Index and Mortality in Intermediate Care Facilities: A Retrospective Study.Journal of clinical medicine · 2021Article
- Multidimensional prognostic index in hospitalized COVID-19 patients with dementia and its relationship with non-invasive ventilation failure.Archives of gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe topic of prognosis in COVID-19 research may be important in adopting appropriate clinical decisions. Multidimensional prognostic index (MPI) is a frailty assessment tool widely used for stratifying prognosis in older people, but data regarding inpatients, affected by COVID-19, are not available.
objectivesTo evaluate whether MPI can predict in-hospital mortality and the admission to intensive care unit (ICU) in older inpatients hospitalized for COVID-19 infection.
methodsIn this longitudinal, Italian, multi-center study, older patients with COVID-19 were included. MPI was calculated using eight different domains typical of comprehensive geriatric assessment and categorized in three groups (MPI 1 ≤ 0.33, MPI 2 0.34-0.66, MPI 3 > 0.66). A multivariable Cox's regression analysis was used reporting the results as hazard ratios (HRs) with 95% confidence intervals (CIs).
results227 older patients hospitalized for SARS-CoV-2 infection were enrolled (mean age: 80.5 years, 59% females). Inpatients in the MPI 3 were subjected less frequently than those in the MPI 1 to non-invasive ventilation (NIV). In the multivariable analysis, people in MPI 3 experienced a higher risk of in hospital mortality (HR = 6.30, 95%CI: 1.44-27.61), compared to MPI 1. The accuracy of MPI in predicting in hospital mortality was good (Area Under the Curve (AUC) = 0.76, 95%CI: 0.68-0.83). People in MPI 3 experienced a significant longer length of stay (LOS) in hospital compared to other participants. No association between MPI and ICU admission was found.
conclusionsFrailty- as assessed by high MPI score - was associated with a significant higher risk of in-hospital mortality, longer LOS, and lower use NIV, whilst the association with ICU admission was not significant. These findings suggest that prognostic stratification by using the MPI could be useful in clinical decision making in older inpatients affected by COVID-19.
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