Evidence map›Paper›PMID 33882313›Full record

ArticleCell reports2021

Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity.

Rodrigo W Alves de Souza, David Gallo, Ghee Rye Lee, Eri Katsuyama, Alexa Schaufler, Janick Weber, Eva Csizmadia, George C Tsokos, Lauren G Koch, Steven L Britton and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Heme Metabolism-Derived Carbon Monoxide Regulates Skeletal Muscle Function.Journal of cachexia, sarcopenia and muscle · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Heme: The Lord of the Iron Ring.Antioxidants (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Rodrigo W Alves de SouzaDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA; School of Physical Education and Sport, University of São Paulo, São Paulo 05508030, Brazil.
David GalloDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Ghee Rye LeeDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Eri KatsuyamaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Alexa SchauflerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Janick WeberDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Eva CsizmadiaDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Lauren G KochDepartment of Physiology & Pharmacology, The University of Toledo, Toledo, OH 43606, USA.
Steven L BrittonDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Ulrik WisløffK.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Patricia C BrumSchool of Physical Education and Sport, University of São Paulo, São Paulo 05508030, Brazil.
Leo E OtterbeinDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lotterbe@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USNorwegian University of Science and Technology · NOUniversidade de São Paulo · BRUniversity of Michigan · USUniversity of Toledo · US

Funding

Examining Carbon Monoxide to Treat Inflammatory Conditions using Experimental Colitis ModelsR01DK119202 · NIDDK · GEORGIA STATE UNIVERSITY · PI OTTERBEIN, LEO E, TAN, CHALET · 2019 to 2023
$3.6M
HBI-002 to Treat Traumatic InjuryR43GM125430 · NIGMS · HILLHURST BIOPHARMACEUTICALS, INC. · PI GOMPERTS, EDWARD, OTTERBEIN, LEO E · 2018 to 2019
$225k
Wohlwend High Pressure Freezer for the BIDMC Electron Microscopy CoreS10OD019988 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HAGEN, SUSAN J · 2015 to 2015
$199k
NIDDK NIH HHS R01 DK119202NIGMS NIH HHS R43 GM125430NIH HHS S10 OD019988
6 · The paper itself

Abstract

Physical exercise has profound effects on quality of life and susceptibility to chronic disease; however, the regulation of skeletal muscle function at the molecular level after exercise remains unclear. We tested the hypothesis that the benefits of exercise on muscle function are linked partly to microtraumatic events that result in accumulation of circulating heme. Effective metabolism of heme is controlled by Heme Oxygenase-1 (HO-1, Hmox1), and we find that mouse skeletal muscle-specific HO-1 deletion (Tam-Cre-HSA-Hmox1

Indexed as

5-Aminolevulinate SynthetaseAnimalsFerrochelataseGene Expression RegulationHemeHeme Oxygenase-1IsoenzymesLow Density Lipoprotein Receptor-Related Protein-1MaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMitochondriaMuscle Fibers, SkeletalMuscle Proteins5-Aminolevulinate SynthetaseALAS2 protein, mouseFerrochelataseHemeHeme Oxygenase-1Hmox1 protein, mouseIsoenzymesLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseMembrane ProteinsMuscle ProteinsMymx protein, mouseMyoD1 myogenic differentiation proteinMyoD ProteinPax7 protein, mousePAX7 Transcription FactorTrim63 protein, mouseTripartite Motif ProteinsUbiquitin-Protein LigasesDAMPexercise traininghemeheme oxygenase-1hemopexinmitochondrial dysfunctionmuscle atrophymuscle microtraumasatellite cells

Identifiers

PMID33882313
PMCPMC8196422
OpenAlexW3154307244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.