ArticleCell reports2021
Phasic Off responses of auditory cortex underlie perception of sound duration.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- A corticohypothalamic circuit that mediates maternal awakening to pup cries.Nature neuroscience · 2026Article
- A computational theory of short-term synaptic plasticity: synapses learn to tell time.Research square · 2026Article
- Computing the effects of excitatory-inhibitory balance on neuronal input-output properties.PLoS computational biology · 2026Article
- Cereblon-related mild intellectual disability disrupts response inhibition and uniformity of group-individual strategies.Frontiers in neuroscience · 2026Article
- The what, which, when, why and who of Off responses in the auditory system.The Journal of physiology · 2025Review
- Experience-dependent maternal defense behavior mediated by profrontal cortical projections to the medial preoptic area in mice.Nature communications · 2025Article
- A spatial code for temporal information is necessary for efficient sensory learning.Science advances · 2025Article
- A new function of offset response in the primate auditory cortex: marker of temporal integration.Communications biology · 2024Article
- A general model unifying the adaptive, transient and sustained properties of ON and OFF auditory neural responses.PLoS computational biology · 2024Article
- Direct contribution of the sensory cortex to the judgment of stimulus duration.Nature communications · 2024Article
- Effective Regulation of Auditory Processing by Parvalbumin Interneurons in the Tail of the Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions.Neuron · 2023Article
- [Comparison of electrophysiological properties of parvalbumin neurons in the tail of the striatum and the auditory cortex of mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Offset Responses in the Auditory Cortex Show Unique History Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- [Auditory response patterns of mouse primary auditory cortex to sound stimuli].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
- Parvalbumin-Positive Interneurons Regulate Cortical Sensory Plasticity in Adulthood and Development Through Shared Mechanisms.Frontiers in neural circuits · 2022Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
It has been proposed that sound information is separately streamed into onset and offset pathways for parallel processing. However, how offset responses contribute to auditory perception remains unclear. Here, loose-patch and whole-cell recordings in awake mouse primary auditory cortex (A1) reveal that a subset of pyramidal neurons exhibit a transient "Off" response, with its onset tightly time-locked to the sound termination and its frequency tuning similar to that of the transient "On" response. Both responses are characterized by excitation briefly followed by inhibition, with the latter mediated by parvalbumin (PV) inhibitory neurons. Optogenetically manipulating sound-evoked A1 responses at different temporal phases or artificially creating phantom sounds in A1 further reveals that the A1 phasic On and Off responses are critical for perceptual discrimination of sound duration. Our results suggest that perception of sound duration is dependent on precisely encoding its onset and offset timings by phasic On and Off responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.