Evidence map›Paper›PMID 33882303›Full record

ArticleCell reports2021

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors.

Joana Ribeiro, Christopher A Procyk, Emma L West, Michelle O'Hara-Wright, Monica F Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 1 synthesis or guideline pooled it, 122 citations in OpenAlex.

  1. Pooled it
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  9. Cell therapy for age-related macular degeneration.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 2 countries.

Joana RibeiroUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Christopher A ProcykUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Emma L WestUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Michelle O'Hara-WrightUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Monica F MartinsUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Majid Moshtagh KhorasaniUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Aura HareUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Mark BascheUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Milan FernandoUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Debbie GohUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Neeraj JumboUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Matteo RizziUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Kate PowellUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Menahil TariqUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Michel MichaelidesUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
James W B BainbridgeUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Alexander J SmithUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Rachael A PearsonUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Anai Gonzalez-CorderoUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Robin R AliUCL Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK; Kellogg Eye Centre, University of Michigan, 1000 Wall St., Ann Arbor, MI 48105, USA. Electronic address: robin.ali@kcl.ac.uk.
University College London · GBW.K. Kellogg Foundation · US

Funding

Medical Research Council MR/J004553/1Medical Research Council MR/R015651/1Medical Research Council MR/T002735/1Medical Research Council MR/T002735/2
6 · The paper itself

Abstract

Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement may restore vision by transplanting healthy cells, which must form new synaptic connections with the recipient retina. Despite recent advances, convincing evidence of functional connectivity arising from transplanted human cone photoreceptors in advanced retinal degeneration is lacking. Here, we show restoration of visual function after transplantation of purified human pluripotent stem cell-derived cones into a mouse model of advanced degeneration. Transplanted human cones elaborate nascent outer segments and make putative synapses with recipient murine bipolar cells (BCs), which themselves undergo significant remodeling. Electrophysiological and behavioral assessments demonstrate restoration of surprisingly complex light-evoked retinal ganglion cell responses and improved light-evoked behaviors in treated animals. Stringent controls exclude alternative explanations, including material transfer and neuroprotection. These data provide crucial validation for photoreceptor replacement therapy and for the potential to rescue cone-mediated vision.

Indexed as

AnimalsBiomarkersCell DifferentiationDependovirusDisease Models, AnimalGene ExpressionGenetic VectorsHumansInduced Pluripotent Stem CellsMacular DegenerationMaleMiceMice, TransgenicMycotoxinsOligopeptidesOrganoidsBiomarkersMycotoxinsOligopeptidesPeripherinsphomopsinPrkca protein, mouseProtein Kinase C-alphaPrph2 protein, mouseReceptors, Glutamatecell therapycone photoreceptordegenerationelectrophysiologymacular degenerationouter segmentrescueretinal organoidtransplantationvisual function

Identifiers

PMID33882303
PMCPMC8065177
OpenAlexW3156311953

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.