Evidence map›Paper›PMID 33882289›Full record

ArticleThe American journal of pathology2021

Vaginal Squamous Cell Carcinoma Develops in Mice with Conditional Arid1a Loss and Gain of Oncogenic Kras Driven by Progesterone Receptor Cre.

Xiyin Wang, Mariana S L Praça, Jillian R H Wendel, Robert E Emerson, Francesco J DeMayo, John P Lydon, Shannon M Hawkins

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. ARID1A in Gynecologic Precancers and Cancers.Reproductive sciences (Thousand Oaks, Calif.) · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiyin WangDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana.
Mariana S L PraçaDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana.
Jillian R H WendelDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana.
Robert E EmersonDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Francesco J DeMayoNational Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
John P LydonDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.
Shannon M HawkinsDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: shhawkin@iu.edu.
Indiana University School of MedicineBaylor College of Medicine · USNational Institute of Environmental Health Sciences · US

Funding

Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5M
REPRODUCTIVE HORMONES: BIOLOGICAL AND MOLECULAR ACTIONSR01HD008188 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$16.3M
SEX HORMONE RECEPTOR COMPONENTS AND THE CELL GENOMER01HD007857 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$14.6M
Molecular Analysis of Uterine ReceptivityR01HD042311 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LYDON, JOHN P · 2009 to 2023
$4.8M
CRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2M
NICHD NIH HHS R01 HD007857NICHD NIH HHS R01 HD008188NICHD NIH HHS R01 HD042311NICHD NIH HHS R24 HD102061
6 · The paper itself

Abstract

Oncogenic KRAS mutations are a common finding in endometrial cancers. Recent sequencing studies indicate that loss-of-function mutations in the ARID1A gene are enriched in gynecologic malignant tumors. However, neither of these genetic insults alone are sufficient to develop gynecologic cancer. To determine the role of the combined effects of deletion of Arid1a and oncogenic Kras, Arid1a

Indexed as

Disease Models, AnimalAnimalsCarcinoma, Squamous CellDisease ProgressionDNA-Binding ProteinsFemaleIntegrasesMiceProto-Oncogene Proteins p21(ras)Receptors, ProgesteroneSquamous Intraepithelial LesionsTranscription FactorsVaginal NeoplasmsArid1a protein, mouseCre recombinaseDNA-Binding ProteinsHras protein, mouseIntegrasesProto-Oncogene Proteins p21(ras)Receptors, ProgesteroneTranscription Factors

Identifiers

PMID33882289
PMCPMC8261476
OpenAlexW3155903514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.