Evidence map›Paper›PMID 33882273›Full record

ArticleBioorganic & medicinal chemistry letters2021

New tetrahydroisoquinoline-based D

Pierpaolo Cordone, Hari K Namballa, Bryant Muniz, Rajat K Pal, Emilio Gallicchio, Wayne W Harding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pierpaolo CordoneDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, United States; Program in Biochemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY 10016, United States.
Hari K NamballaDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, United States.
Bryant MunizDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, United States.
Rajat K PalProgram in Biochemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY 10016, United States; Department of Chemistry, Brooklyn College, 2900 Bedford Avenue, Brooklyn New York, NY, 11210, United States.
Emilio GallicchioProgram in Biochemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY 10016, United States; Program in Chemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY 10016, United States; Department of Chemistry, Brooklyn College, 2900 Bedford Avenue, Brooklyn New York, NY, 11210, United States.
Wayne W HardingDepartment of Chemistry, Hunter College, City University of New York, 695 Park Avenue, NY 10065, United States; Program in Biochemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY 10016, United States; Program in Chemistry, CUNY Graduate Center, 365 5th Avenue, New York, NY 10016, United States. Electronic address: whardi@hunter.cuny.edu.

Funding

Novel anti-cocaine D1 partial agonistsSC1DA049961 · NIDA · HUNTER COLLEGE · PI HARDING, WAYNE WESLEY · 2019 to 2022
$1.6M
NIDA NIH HHS SC1 DA049961
6 · The paper itself

Abstract

The effect of rigidification of the n-butyl linker region of tetrahydroisoquinoline-containing D

Indexed as

Dose-Response Relationship, DrugHumansLigandsMolecular StructureReceptors, Dopamine D3Structure-Activity RelationshipTetrahydroisoquinolinesXylenes1,2,3,4-tetrahydroisoquinoline2-xyleneLigandsReceptors, Dopamine D3TetrahydroisoquinolinesXylenesD(3)RDockingDopamine receptorTetrahydroisoquinolineσ(2)R

Identifiers

PMID33882273
PMCPMC8165021

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.