Evidence map›Paper›PMID 33882026›Full record

Trial reportAging2021

Effects of multi-domain lifestyle interventions on sarcopenia measures and blood biomarkers: secondary analysis of a randomized controlled trial of community-dwelling pre-frail and frail older adults.

Yanxia Lu, Mathew Niti, Keng Bee Yap, Crystal Tze Ying Tan, Ma Shwe Zin Nyunt, Liang Feng, Boon Yeow Tan, Gribson Chan, Sue Anne Khoo, Sue Mei Chan and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 6 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  6. Pooled it
  7. Trial
  8. Review
  9. Article
  10. Prevention of Sarcopenia.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Yanxia LuDepartment of Medical Psychology and Ethics, School of Basic Medical Sciences, Shandong University, Jinan 250012, China.
Mathew NitiPerformance and Technology Assessment Department, Ministry of Health, Singapore.
Keng Bee YapGeriatric Medicine and Palliative Medicine Department, Ng Teng Fong General Hospital, Singapore.
Crystal Tze Ying TanBiology of Ageing Laboratory, Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Singapore.
Ma Shwe Zin NyuntGerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Liang FengGerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Boon Yeow TanMedical Services Department, St Luke's Hospital, Singapore.
Gribson ChanRehabilitation Services Division, St Luke's Hospital, Singapore.
Sue Anne KhooPsychological Medicine Department, Khoo Teck Puat Hospital, Singapore.
Sue Mei ChanNutrition and Dietetics Department, Khoo Teck Puat Hospital, Singapore.
Philip YapGeriatric Medicine Department, Khoo Teck Puat Hospital, Singapore.
Anis LarbiBiology of Ageing Laboratory, Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Singapore.
Tze Pin NgGerontology Research Programme, Department of Psychological Medicine, National University Health System, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Khoo Teck Puat Hospital · SGNational University of Singapore · SGSt Luke's Hospital · SGMinistry of Health · SGNg Teng Fong General Hospital · SGShandong University · CNSingapore Immunology Network · SGUniversité de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Few studies have comprehensively described changes in blood biomarkers of the physiological responses underlying sarcopenia reduction associated with lifestyle interventions. In this study, we performed secondary analyses of data in a randomized controlled trial of multi-domain lifestyle interventions (6-month duration physical exercise, nutritional enrichment, cognitive training, combination and standard care control) among 246 community-dwelling pre-frail and frail elderly, aged ≥65 years, with and without sarcopenia. Appendicular lean mass (ALM), lower limb strength, gait speed, and blood levels of markers of muscle metabolism, inflammation, anti-oxidation, anabolic hormone regulation, insulin signaling, tissue oxygenation were measured at baseline, 3-month and 6-month post-intervention. Multi-domain interventions were associated with significant (p < 0.001) reduction of sarcopenia at 3-month and 6-month post-intervention, improved gait speed, enhanced lower limb strength, and were equally evident among sarcopenic participants who were slower at baseline than non-sarcopenic participants. Active intervention was associated with significantly reduced inflammation levels. Sarcopenia status and reduction were associated with blood biomarkers related to muscle metabolism, steroid hormone regulation, insulin-leptin signaling, and tissue oxygenation. Physical, nutritional and cognitive intervention was associated with measures of sarcopenia reduction, together with changes in circulating biomarkers of anabolic and catabolic metabolism underlying sarcopenia.

Indexed as

Life StyleAgedBiomarkersExerciseFemaleFrail ElderlyFrailtyHumansIndependent LivingMaleMuscle StrengthSarcopeniaTreatment OutcomeBiomarkershomeostasisinflammationlifestyle interventionrandomized controlled trialsarcopenia

Identifiers

PMID33882026
PMCPMC8064206
OpenAlexW3137617958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.