Evidence map›Paper›PMID 33881939›Full record

ArticleJournal of neurophysiology2021

Young DAPK1 knockout mice have altered presynaptic function.

Dayton J Goodell, Jonathan E Tullis, K Ulrich Bayer

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Synaptic Plasticity as a Function of the Temporal Derivative.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dayton J GoodellDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Jonathan E TullisDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
K Ulrich BayerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
University of Colorado Anschutz Medical Campus · US

Funding

PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
Postsynaptic kinase/phosphatase networks in amyloid beta-induced synaptic dysfunctionR01NS110383 · NINDS · UNIVERSITY OF COLORADO DENVER · PI MARK L DELL'ACQUA, Matthew J Kennedy · 2018 to 2026
$5.2M
CaMKII substrate-selection in opposing forms of synaptic plasticityR01NS081248 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2013 to 2026
$4.9M
CaMKII in global cerebral ischemia: mechanisms and therapeutic interventionR01NS118786 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2021 to 2025
$1.9M
DAPK1 regulation and involvement in LTDF31NS092265 · NINDS · UNIVERSITY OF COLORADO DENVER · PI GOODELL, DAYTON JOSHUA · 2015 to 2017
$86k
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31NS092265HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS081248HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS110383HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS118786NIGMS NIH HHS T32 GM007635NINDS NIH HHS F31 NS092265NINDS NIH HHS R01 NS081248NINDS NIH HHS R01 NS110383NINDS NIH HHS R01 NS118786
6 · The paper itself

Abstract

The death-associated protein kinase 1 (DAPK1) has recently been shown to have a physiological function in long-term depression (LTD) of glutamatergic synapses: acute inhibition of DAPK1 blocked the LTD that is normally seen at the hippocampal CA1 synapse in young mice, and a pharmacogenetic combination approach showed that this specifically required DAPK1-mediated suppression of postsynaptic Ca

Indexed as

AnimalsCA1 Region, HippocampalCells, CulturedDeath-Associated Protein KinasesElectrophysiological PhenomenaGlutamic AcidLong-Term PotentiationLong-Term Synaptic DepressionMiceMice, Inbred C57BLMice, KnockoutDapk1 protein, mouseDeath-Associated Protein KinasesGlutamic AcidDAPK1glutamate releaseLTD

Identifiers

PMID33881939
PMCPMC8356766
OpenAlexW3154026152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.