Evidence map›Paper›PMID 33881927›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT.

Christian Westöö, Christian Norvik, Niccolò Peruzzi, Oscar van der Have, Goran Lovric, Ida Jeremiasen, Phan-Kiet Tran, Rajmund Mokso, Vinicio de Jesus Perez, Hans Brunnström and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Endothelial Heterogeneity in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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  19. Review
  20. Intrapulmonary Bronchopulmonary Anastomoses in Severe COVID-19-related Acute Respiratory Failure.American journal of respiratory and critical care medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Christian WestööDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Christian NorvikDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Niccolò PeruzziDepartment of Clinical Sciences, Division of Medical Radiation Physics, Lund University, Lund, Sweden.
Oscar van der HaveDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Goran LovricCentre d'Imagerie BioMédicale, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Ida JeremiasenDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Phan-Kiet TranChildren's Heart Center, Skåne University Hospital, Lund, Sweden.
Rajmund MoksoMax IV Laboratory, Lund University, Lund, Sweden.
Vinicio de Jesus PerezStanford University Medical Center, Palo Alto, California.
Hans BrunnströmDepartment of Clinical Sciences Lund, Division of Pathology, Lund University, Lund, Sweden.ORCID 0000-0001-7402-138X
Martin BechDepartment of Clinical Sciences, Division of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID 0000-0001-9109-7175
Csaba GalambosDepartment of Pathology and Laboratory Medicine, Children's Hospital Colorado, Aurora, Colorado.
Karin Tran-LundmarkDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Lund University · SEChildren's Hospital Colorado · USPaul Scherrer Institute · CHSkåne University Hospital · SEStanford Medicine · US

Funding

HHS | National Institutes of Health (NIH) R01HL06702
6 · The paper itself

Abstract

In pulmonary arterial hypertension, plexiform lesions are associated with severe arterial obstruction and right ventricular failure. Exploring their structure and position is crucial for understanding the interplay between hemodynamics and vascular remodeling. The aim of this research was to use synchrotron-based phase-contrast micro-CT to study the three-dimensional structure of plexiform lesions. Archived paraffin-embedded tissue samples from 14 patients with pulmonary arterial hypertension (13 idiopathic, 1 with known

Indexed as

AdultCase-Control StudiesFamilial Primary Pulmonary HypertensionFemaleHemodynamicsHumansMaleMicroscopy, Phase-ContrastPulmonary ArterySynchrotronsVascular RemodelingX-Ray Microtomographyimaginglungplexiform lesionpulmonary arterial hypertensionsynchrotron

Identifiers

PMID33881927
PMCPMC8321861
OpenAlexW3154304496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.