ArticleJCO oncology practice2021
Predictors of Unplanned Hospitalizations Among Older Adults Receiving Cancer Chemotherapy.
Article in JCO oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 30 citations in OpenAlex.
- Exploring geriatric assessment-driven rehabilitation referral patterns and its influence on functional outcomes and survival in older adults with advanced cancer.Journal of the American Geriatrics Society · 2025Trial
- Trial
- Effect of polypharmacy and potentially inappropriate medications on physical functional decline among older adults with advanced cancer receiving systemic treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Trial
- Effects of a Geriatric Assessment Intervention on Patient-Reported Symptomatic Toxicity in Older Adults With Advanced Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Trial
- Polypharmacy, Potentially Inappropriate Medications, and Drug-Drug Interactions in Vulnerable Older Adults With Advanced Cancer Initiating Cancer Treatment.The oncologist · 2022Trial
- Potentially preventable unplanned hospitalizations due to adverse events in patients receiving systemic anticancer therapy: a retrospective single-center study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Treatment Tolerability in Older Adults With Advanced Cancer Receiving Geriatric Assessment-Guided Versus Oncologist-Guided Primary Treatment Modification: Secondary Analysis of the GAP70+ Trial.JCO oncology practice · 2026Article
- Acute Care Utilization Patterns During Chemotherapy and Predictive Model Development at a Rural Community Cancer Center.JCO clinical cancer informatics · 2025Article
- Gastrointestinal Symptoms During Cancer Therapy: The Clinician's Role.Advances in nutrition (Bethesda, Md.) · 2025Article
- Investigating Factors Related to Length of Hospital Stay in Male Patients With Lung Cancer Undergoing Chemotherapy.Cureus · 2025Article
- Cumulative frailty impact on unplanned hospitalization in older patients with cancer and excellent Eastern Cooperative Oncology Group performance.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Poor survival of metastatic cancer patients hospitalized due to immune checkpoint inhibitor-related adverse events.Immunotherapy · 2025Article
- Geriatric Assessment-driven INterventions among Hospitalized older adults with cancer (GAIN-HOSP), a prospective pilot study.Journal of geriatric oncology · 2025Article
- Associations Between Rehabilitation Utilization and Out-of-Pocket Costs Among Older Adults With Breast Cancer in the United States.Archives of physical medicine and rehabilitation · 2024Article
- How to incorporate chronic health conditions in oncologic decision-making and care for older patients with cancer? A survey among healthcare professionals.European geriatric medicine · 2024Article
- Addressing Disability in Cancer Survivors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Spatiotemporal Patterns of Hospitalizations Among Older Adults With Co-Presence of Cancer and Dementia in US Counties: 2013-2018.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Article
- Article
- How old is too old? Frailty and geriatric assessments of older patients undergoing allogeneic HCT.Hematology. American Society of Hematology. Education Program · 2023Article
- An objective assessment in newly diagnosed multiple myeloma to avoid treatment complications and strengthen therapy adherence.Haematologica · 2023Article
Corrections and comments
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Authors and funding
20 authors at 10 institutions in 1 country.
Funding
Abstract
purposeHospitalizations during cancer treatment are costly, can impair quality of life, and negatively affect therapy completion. Our objective was to identify risk factors for unplanned hospitalization among older adults receiving chemotherapy.
methodsThis is a secondary analysis of a multisite cohort study (N = 750) of patients ≥ 65 years of age evaluated with a geriatric assessment (GA) to predict chemotherapy toxicity. The primary outcome of this analysis was unplanned hospitalizations during treatment; the secondary outcome was length of stay (LOS) of the first hospitalization. Independent variables included pretreatment GA measures, laboratory values, cancer type and stage, and treatment intensity characteristics. We used logistic regression to estimate the odds of hospitalization and generalized linear models for LOS in multivariable analyses.
resultsThe sample median age was 72 years (range, 65-94 years); 59% had stage IV disease. At least one unplanned hospitalization occurred in 193 patients (25.7%) during receipt of chemotherapy. In multivariable analyses controlling for cancer type, the following baseline characteristics were significantly associated with increased odds of hospitalization: needing help bathing or dressing (odds ratio [OR], 1.8; 95% CI, 1.0 to 3.1), polypharmacy (≥ 5 meds) (OR, 1.6; 95% CI, 1.1 to 2.4), more comorbid conditions (OR, 1.1; 95% CI, 1.0 to 1.3), availability of someone to take them to the doctor (OR, 2.0; 95% CI, 1.0 to 4.1), CrCl < 60 mL/min (OR, 1.7; 95% CI, 1.1 to 2.4), and albumin < 3.5 g/dL (OR, 1.8; 95% CI, 1.2 to 2.8). In multivariable analyses, older age, self-reported presence of liver or kidney disease, living alone and depressive symptoms were associated with longer LOS.
conclusionReadily available GA variables and laboratory data, but not age, were associated with unplanned hospitalizations among older adults receiving chemotherapy. If validated, these data can inform prediction models and the design of interventions to decrease unplanned hospitalizations.
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