ArticleAngewandte Chemie (International ed. in English)2021
Molecular Origin of Blood-Based Infrared Spectroscopic Fingerprints*.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Multidimensional Infrared Spectroscopy as a Bioanalytical Technique.Chemical reviews · 2026Review
- Enhancing Vibrational Spectroscopy-Based Diagnosis through Bottom-Up Modeling: The Case of Infrared Absorption Spectrum of Urine.Analytical chemistry · 2026Article
- Bridging Spectral Gaps: Cross-Device Model Generalization in Blood-Based Infrared Spectroscopy.Analytical chemistry · 2025Article
- Electric-Field Molecular Fingerprinting to Probe Cancer.ACS central science · 2025Article
- Online coupling of size exclusion chromatography to capillary-enhanced Raman spectroscopy for the identification of protein classes in hemolyzed blood serum.Analytical and bioanalytical chemistry · 2025Article
- The Perils of Molecular Interpretations from Vibrational Spectra of Complex Samples.Angewandte Chemie (International ed. in English) · 2024Review
- Plasma infrared fingerprinting with machine learning enables single-measurement multi-phenotype health screening.Cell reports. Medicine · 2024Article
- Using 2D-IR Spectroscopy to Measure the Structure, Dynamics, and Intermolecular Interactions of Proteins in HAccounts of chemical research · 2024Review
- Distinguishing IDH mutation status in gliomas using FTIR-ATR spectra of peripheral blood plasma indicating clear traces of protein amyloid aggregation.BMC cancer · 2024Article
- Limits and Prospects of Molecular Fingerprinting for Phenotyping Biological Systems Revealed throughAnalytical chemistry · 2023Article
- Observational
- Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer.eLife · 2021Article
- Molecular Origin of Blood-Based Infrared Spectroscopic Fingerprints*.Angewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infrared spectroscopy of liquid biopsies is a time- and cost-effective approach that may advance biomedical diagnostics. However, the molecular nature of disease-related changes of infrared molecular fingerprints (IMFs) remains poorly understood, impeding the method's applicability. Here we probe 148 human blood sera and reveal the origin of the variations in their IMFs. To that end, we supplemented infrared spectroscopy with biochemical fractionation and proteomic profiling, providing molecular information about serum composition. Using lung cancer as an example of a medical condition, we demonstrate that the disease-related differences in IMFs are dominated by contributions from twelve highly abundant proteins-that, if used as a pattern, may be instrumental for detecting malignancy. Tying proteomic to spectral information and machine learning advances our understanding of the infrared spectra of liquid biopsies, a framework that could be applied to probing of any disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.