Evidence map›Paper›PMID 33881641›Full record

ArticleClinical and experimental nephrology2021

Comparison of annual eGFR decline among primary kidney diseases in patients with CKD G3b-5: results from a REACH-J CKD cohort study.

Junichi Hoshino, Ryoya Tsunoda, Kei Nagai, Hirayasu Kai, Chie Saito, Yukiko Ito, Koichi Asahi, Masahide Kondo, Kunitoshi Iseki, Chiho Iseki and 8 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Junichi HoshinoNephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, 105-8470, Japan. hoshino@toranomon.gr.jp.ORCID http://orcid.org/0000-0002-0444-101X
Ryoya TsunodaDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Kei NagaiDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Hirayasu KaiDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Chie SaitoDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Yukiko ItoTsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Koichi AsahiDepartment of Nephrology and Hypertension, Iwate Medical University, Morioka, Japan.
Masahide KondoDepartment of Health Care Policy and Health Economics, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kunitoshi IsekiOkinawa Heart and Renal Association, Naha, Okinawa, Japan.
Chiho IsekiOkinawa Heart and Renal Association, Naha, Okinawa, Japan.
Hirokazu OkadaDepartment of Nephrology, Saitama Medical University, Saitama, Japan.
Naoki KashiharaDepartment of Nephrology and Hypertension, Kawasaki Medical School, Okayama, Japan.
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Takashi WadaDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Ishikawa, Japan.
Christian CombeUnité INSERM 1026 Biotis, Univ. Bordeaux, Bordeaux, France.
Ronald L PisoniArbor Research Collaborative for Health, Ann Arbor, MI, USA.
Bruce M RobinsonArbor Research Collaborative for Health, Ann Arbor, MI, USA.
Kunihiro YamagataDepartment of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. k-yamaga@md.tsukuba.ac.jp.
University of Tsukuba · JPArbor Research Collaborative for Health · USIwate Medical University · JPKanazawa University · JPKawasaki Medical School · JPNiigata University · JPSaitama Medical University · JPToranomon Hospital · JPUniversité de Bordeaux · FR

Funding

Japan Society for the Promotion of Science 15K08719Japan Society for the Promotion of Science 18K08227
6 · The paper itself

Abstract

backgroundDisease-specific trajectories of renal function in advanced chronic kidney disease (CKD) are not well defined. Here, we compared these trajectories in the estimated glomerular filtration rate (eGFR) by CKD stages.

methodsPatients with multiple eGFR measurements during the 5-year preregistration period of the REACH-J study were enrolled. Mean annual eGFR declines were calculated from linear mixed effect models with the adjustment variables of baseline CKD stage, age, sex and the current CKD stage and the level of proteinuria (CKDA1-3).

resultsAmong 1,969 eligible patients with CKDG3b-5, the adjusted eGFR decline (ml/min/1.73 m

conclusionOur study revealed the disease-specific annual eGFR declines by CKD stages and the level of proteinuria. Comparing to the other kidney diseases, the declines in PKD patients were getting faster from early stages of CKD. These results suggest the importance of CKD managements in PKD patients from the early stages.

Indexed as

Glomerular Filtration RateAgedAged, 80 and overDiabetic NephropathiesFemaleHumansKidney Failure, ChronicMaleMiddle AgedPolycystic Kidney DiseasesProspective StudiesDiabetic kidney diseaseEGFR declinePolycystic kidney diseaseREACH-J

Identifiers

PMID33881641
OpenAlexW3156815556

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.