ArticleEJNMMI research2021
Correlation of [
Article in EJNMMI research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts.Annals of neurology · 2025Article
- Impact of shortening time on diagnosis ofEJNMMI research · 2024Article
- Radiomics-Based Artificial Intelligence Differentiation of Neurodegenerative Diseases with Reference to the Volumetry.Life (Basel, Switzerland) · 2022Article
- Research progress in neuroimaging of sporadic early-onset Alzheimer's disease.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundWhen Alzheimer's disease (AD) is occurring at an early onset before 65 years old, its clinical course is generally more aggressive than in the case of a late onset. We aim at identifying [[Formula: see text]F]florbetaben PET biomarkers sensitive to differences between early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). We conducted [[Formula: see text]F]florbetaben PET/CT scans of 43 newly diagnosed AD subjects. We calculated 93 textural parameters for each of the 83 Hammers areas. We identified 41 independent principal components for each brain region, and we studied their Spearman correlation with the age of AD onset, by taking into account multiple comparison corrections. Finally, we calculated the probability that EOAD and LOAD patients have different amyloid-[Formula: see text] ([Formula: see text]) deposition by comparing the mean and the variance of the significant principal components obtained in the two groups with a 2-tailed Student's t-test.
resultsWe found that four principal components exhibit a significant correlation at a 95% confidence level with the age of onset in the left lateral part of the anterior temporal lobe, the right anterior orbital gyrus of the frontal lobe, the right lateral orbital gyrus of the frontal lobe and the left anterior part of the superior temporal gyrus. The data are consistent with the hypothesis that EOAD patients have a significantly different [[Formula: see text]F]florbetaben uptake than LOAD patients in those four brain regions.
conclusionsEarly-onset AD implies a very irregular pattern of [Formula: see text] deposition. The authors suggest that the identified textural features can be used as quantitative biomarkers for the diagnosis and characterization of EOAD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.