ArticleBlood2021
Radiation-induced bystander effects impair transplanted human hematopoietic stem cells via oxidative DNA damage.
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Article in Blood, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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38citing papers in PubMed, 1 pooled it
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38 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Advances in the Regulation of Hematopoietic Homeostasis by Programmed Cell Death Under Radiation Conditions.Stem cell reviews and reports · 2025Pooled it
- Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial.BMC medicine · 2022Trial
- Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self-antigens.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Functional equivalence of γ- and x-ray irradiation for long-term peripheral blood chimerism and acute myeloid leukemia transplant outcomes in mice.Experimental hematology · 2026Article
- Diallyl disulfide reduces oxidative stress to mitigate uranium tailings radiation-induced damage to the hematopoietic system.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Mesenchymal stromal cells modulate survival and regeneration of human hematopoietic stem cells via PGE2/cAMP signaling.Cell death & disease · 2026Article
- Mechanistic trends and therapeutic targets in Radiation-Induced apoptosis: A bibliometric and translational mapping.Radiation and environmental biophysics · 2026Review
- Closed, pumpless microphysiological system with unidirectional flow for co-culture and focal irradiation.RSC advances · 2026Article
- Association between pelvic bone marrow dosimetry and acute hematologic toxicity during concurrent chemoradiotherapy for gynecologic malignancies.Journal of radiation research · 2026Article
- Post-irradiation dietary restriction impairs hematopoiesis via inhibition of the pentose phosphate pathway in hematopoietic stem and progenitor cells.Cell death & disease · 2026Article
- Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- TGF-β1-triggered maladaptive bone marrow endothelium impedes hematopoietic recovery.Signal transduction and targeted therapy · 2025Article
- Ferumoxytol promotes haematopoietic stem cell post-injury regeneration as a reactive oxygen species scavenger.Nature nanotechnology · 2025Article
- Single-cell transcriptomics reveals BMP4-BMPR2 signaling promotes radiation resistance in hematopoietic stem cells following injury.Nature communications · 2025Article
- Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.The Journal of clinical investigation · 2025Article
- Vanillic acid inhibits TGF-β type I receptor to protect bone marrow mesenchymal stem cells from radiation-induced bystander effects.Translational cancer research · 2025Article
- Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis.Cell communication and signaling : CCS · 2024Article
- Impairment of Renal and Hematopoietic Stem/Progenitor Cell Compartments in Frailty Syndrome: Link With Oxidative Stress, Plasma Cytokine Profiles, and Nuclear DNA Damage.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
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Authors and funding
23 authors at 2 institutions in 1 country.
Linping HuState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.ORCID 0000-0002-6606-3843
Xiuxiu YinState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Yawen ZhangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.ORCID 0000-0001-9613-4721
Aiming PangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Xiaowei XieState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Shangda YangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.ORCID 0000-0002-9235-4847
Caiying ZhuState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Yapu LiState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Biao ZhangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Yaojin HuangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Yunhong TianDepartment of Intensive Care Unit, Key Laboratory for Critical Care Medicine of the Ministry of Health, Emergency Medicine Research Institute, Tianjin First Center Hospital, School of Medicine, Nankai University, Tianjin, China; and.
Mei WangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Wenbin CaoState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Shulian ChenState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Yawei ZhengState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Shihui MaState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Fang DongState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Sha HaoState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Sizhou FengState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Yongxin RuState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Hui ChengState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.
Erlie JiangState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.ORCID 0000-0002-3937-5518
Tao ChengState Key Laboratory of Experimental Hematology, National Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine and Department of Stem Cell & Regenerative Medicine, Chinese Academy of Medical Sciences-Peking Union Medical College, Tianjin, China.ORCID 0000-0002-5925-2769
Chinese Academy of Medical Sciences & Peking Union Medical College · CNNankai University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total body irradiation (TBI) is commonly used in host conditioning regimens for human hematopoietic stem cell (HSC) transplantation to treat various hematological disorders. Exposure to TBI not only induces acute myelosuppression and immunosuppression, but also injures the various components of the HSC niche in recipients. Our previous study demonstrated that radiation-induced bystander effects (RIBE) of irradiated recipients decreased the long-term repopulating ability of transplanted mouse HSCs. However, RIBE on transplanted human HSCs have not been studied. Here, we report that RIBE impaired the long-term hematopoietic reconstitution of human HSCs as well as the colony-forming ability of human hematopoietic progenitor cells (HPCs). Our further analyses revealed that the RIBE-affected human hematopoietic cells showed enhanced DNA damage responses, cell-cycle arrest, and p53-dependent apoptosis, mainly because of oxidative stress. Moreover, multiple antioxidants could mitigate these bystander effects, though at different efficacies in vitro and in vivo. Taken together, these findings suggest that RIBE impair human HSCs and HPCs by oxidative DNA damage. This study provides definitive evidence for RIBE on transplanted human HSCs and further justifies the necessity of conducting clinical trials to evaluate different antioxidants to improve the efficacy of HSC transplantation for the patients with hematological or nonhematological disorders.
Indexed as
DNA DamageHematopoietic Stem Cell TransplantationAnimalsBystander EffectFemaleGamma RaysHematopoietic Stem CellsHeterograftsHumansMiceMice, Inbred NODMice, SCIDOxidative StressRadiation Injuries, Experimental
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