ArticleJournal of medicinal chemistry2021
A Modular Synthetic Route Involving
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Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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Who cites it
20 citing papers in PubMed.
- Article
- Multi-Halogenated Indoles as Antimicrobial and Antivirulence Agents Against Drug-Resistant Staphylococcus aureus.Microbial biotechnology · 2025Article
- Halogenated quinoline kill agent rapidly induces iron starvation ofMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2025Article
- AlleviatingAnimals : an open access journal from MDPI · 2025Article
- Antibiofilm Activities of Multiple Halogenated Pyrimidines AgainstInternational journal of molecular sciences · 2024Article
- Recent Advances in Phenazine Natural Products: Chemical Structures and Biological Activities.Molecules (Basel, Switzerland) · 2024Review
- Design, synthesis and evaluation of halogenated phenazine antibacterial prodrugs targeting nitroreductase enzymes for activation.RSC medicinal chemistry · 2023Article
- Photoswitchable dynamic conjugate addition-elimination reactions as a tool for light-mediated click and clip chemistry.Nature communications · 2023Article
- Identification of Multiple Iron Uptake Mechanisms in Enterococcus faecalis and Their Relationship to Virulence.Infection and immunity · 2023Article
- Design, Synthesis, and Evaluation of Carbonate-Linked Halogenated Phenazine-Quinone Prodrugs with Improved Water-Solubility and Potent Antibacterial Profiles.ACS infectious diseases · 2023Article
- Transcript Profiling of Nitroxoline-Treated Biofilms Shows Rapid Up-regulation of Iron Acquisition Gene Clusters.ACS infectious diseases · 2022Article
- Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis.Cellular and molecular life sciences : CMLS · 2022Article
- Mechanistic Studies andJournal of medicinal chemistry · 2022Article
- Comparative Studies to Uncover Mechanisms of Action ofACS infectious diseases · 2022Article
- Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-ResistantACS infectious diseases · 2022Article
- Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery.Molecules (Basel, Switzerland) · 2022Review
- Ruthenium polypyridine complexes with triphenylamine groups as antibacterial agents againstFrontiers in chemistry · 2022Article
- Design, synthesis, and antibacterial activity ofRSC medicinal chemistry · 2021Article
- An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications.Organic & biomolecular chemistry · 2021Article
- Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.Journal of medicinal chemistry · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Hongfen YangDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8367-4104
Shivani KundraDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0003-0711-1646
Michaelle ChojnackiDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, United States.ORCID 0000-0003-0245-9918
Ke LiuDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-6827-6706
Marisa A FuseBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.
Yasmeen AbouelhassanDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Dimitris KallifidasDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Peilan ZhangDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-6417-6417
Guangtao HuangDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville Florida 32610, United States.
Shouguang JinDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville Florida 32610, United States.ORCID 0000-0002-6447-6978
Yousong DingDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8610-0659
Hendrik LueschDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-4091-7492
Kyle H RohdeBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32827, United States.ORCID 0000-0001-9838-3238
Paul M DunmanDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, United States.
José A LemosDepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0003-0791-5863
Robert W HuigensDepartment of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0003-3811-2721
Funding
NIH Equipment Supplement to R35GM128742R35GM128742 · NIGMS · UNIVERSITY OF FLORIDA · PI Yousong Ding · 2018 to 2026
$3.4MIndole Alkaloids and Phenazine Antibiotics: New Platforms for Drug DiscoveryR35GM128621 · NIGMS · UNIVERSITY OF FLORIDA · PI HUIGENS, ROBERT WILLIAM · 2018 to 2022
$1.7MAcquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600kSignificance of metal homeostasis to bacterial pathogenesis in chronic woundsR21AI137446 · NIAID · UNIVERSITY OF FLORIDA · PI LEMOS, JOSE A, WALLET, SHANNON MARGARET · 2018 to 2019
$419kNIAID NIH HHS R21 AI137446NIGMS NIH HHS R35 GM128621NIGMS NIH HHS R35 GM128742NIH HHS S10 OD021758
Abstract
Pathogenic bacteria demonstrate incredible abilities to evade conventional antibiotics through the development of resistance and formation of dormant, surface-attached biofilms. Therefore, agents that target and eradicate planktonic and biofilm bacteria are of significant interest. We explored a new series of halogenated phenazines (HP) through the use of
Indexed as
Aniline CompoundsAnimalsAnti-Bacterial AgentsBiofilmsCell LineCell SurvivalDisease Models, AnimalDrug DesignFemaleHalogenationHumansIronIron DeficienciesMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred BALB CanilineAniline CompoundsAnti-Bacterial AgentsIronPhenazines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.