Evidence map›Paper›PMID 33881306›Full record

ArticleACS synthetic biology2021

Increasing MinD's Membrane Affinity Yields Standing Wave Oscillations and Functional Gradients on Flat Membranes.

Simon Kretschmer, Tamara Heermann, Andrea Tassinari, Philipp Glock, Petra Schwille

Open access · hybridAbstract read
In one paragraph

Article in ACS synthetic biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Simon KretschmerDepartment of Cellular and Molecular Biophysics, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.ORCID 0000-0002-0825-174X
Tamara HeermannDepartment of Cellular and Molecular Biophysics, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.ORCID 0000-0003-1607-0727
Andrea TassinariDepartment of Cellular and Molecular Biophysics, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Philipp GlockDepartment of Cellular and Molecular Biophysics, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Petra SchwilleDepartment of Cellular and Molecular Biophysics, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.ORCID 0000-0002-6106-4847
Max Planck Institute of Biochemistry · DEUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of large-scale patterns through molecular self-organization is a basic principle of life. Accordingly, the engineering of protein patterns and gradients is of prime relevance for synthetic biology. As a paradigm for such pattern formation, the bacterial MinDE protein system is based on self-organization of the ATPase MinD and ATPase-activating protein MinE on lipid membranes. Min patterns can be tightly regulated by tuning physical or biochemical parameters. Among the biochemically engineerable modules, MinD's membrane targeting sequence, despite being a key regulating element, has received little attention. Here we attempt to engineer patterns by modulating the membrane affinity of MinD. Unlike the traveling waves or stationary patterns commonly observed

Indexed as

Adenosine TriphosphatasesCell Cycle ProteinsCell MembraneEscherichia coliEscherichia coli ProteinsLipid BilayersMembrane ProteinsMutant ProteinsPlasmidsProtein EngineeringSynthetic BiologyAdenosine TriphosphatasesCell Cycle ProteinsEscherichia coli ProteinsLipid BilayersMembrane ProteinsMinD protein, E coliMinE protein, E coliMutant Proteinsin vitro reconstitutionMin proteinspattern engineeringpattern formationreaction-diffusion systemself-organization

Identifiers

PMID33881306
PMCPMC8155659
OpenAlexW3156029830

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.