Evidence map›Paper›PMID 33881232›Full record

ArticleIET systems biology2021

Effects of noise and time delay on E2F's expression level in a bistable Rb-E2F gene's regulatory network.

John Billy Kirunda, Lijian Yang, Lulu Lu, Ya Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IET systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John Billy KirundaDepartment of Physics and Institute of Biophysics, Central China Normal University, Wuhan, China.
Lijian YangDepartment of Physics and Institute of Biophysics, Central China Normal University, Wuhan, China.ORCID 0000-0003-2363-9168
Lulu LuDepartment of Physics and Institute of Biophysics, Central China Normal University, Wuhan, China.
Ya JiaDepartment of Physics and Institute of Biophysics, Central China Normal University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bistable Rb-E2F gene regulatory network plays a central role in regulating cellular proliferation-quiescence transition. Based on Gillespie's chemical Langevin method, the stochastic bistable Rb-E2F gene's regulatory network with time delays is proposed. It is found that under the moderate intensity of internal noise, delay in the Cyclin E synthesis rate can greatly increase the average concentration value of E2F. When the delay is considered in both E2F-related positive feedback loops, within a specific range of delay (3-13)

Indexed as

Gene Regulatory NetworksCell CycleCell ProliferationE2F Transcription FactorsE2F Transcription Factors

Identifiers

PMID33881232
PMCPMC8675803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.