Evidence map›Paper›PMID 33881041›Full record

ReviewLab on a chip2021

Emerging point-of-care technologies for anemia detection.

Ran An, Yuning Huang, Yuncheng Man, Russell W Valentine, Erdem Kucukal, Utku Goreke, Zoe Sekyonda, Connie Piccone, Amma Owusu-Ansah, Sanjay Ahuja and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Lab on a chip, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ran AnMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu.
Yuning HuangMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu.
Yuncheng ManMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu.ORCID 0000-0002-3034-5523
Russell W ValentineMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu.
Erdem KucukalMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu.
Utku GorekeMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu.
Zoe SekyondaBiomedical Engineering Department, Case Western Reserve University, Cleveland, OH, USA.
Connie PicconeDepartment of Pediatric Hematology, Carle Foundation Hospital, Urbana, IL, USA.
Amma Owusu-AnsahDepartment of Pediatrics, Division of Hematology and Oncology, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Sanjay AhujaDepartment of Pediatrics, Division of Hematology and Oncology, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Jane A LittleDivision of Hematology & UNC Blood Research Center, Department of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Umut A GurkanMechanical and Aerospace Engineering Department, Case Western Reserve University, 10900 Euclid Ave., Glennan Building, Cleveland, OH 44106, USA. umut@case.edu and Biomedical Engineering Department, Case Western Reserve University, Cleveland, OH, USA and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-0331-9960
Case Western Reserve University · USPalmetto Hematology Oncology · USCarle Foundation Hospital · USCommunities In Schools of Orange County · US

Funding

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Nathaniel Scott Hafer · 2018 to 2026
$141.0M
HLS-Affordable, quantitative microchip-electrophoresis for sickle cell disease screeningR44HL140739 · NHLBI · HEMEX HEALTH, INC. · PI GALEN, PETER · 2018 to 2025
$4.7M
Standardized Monitoring of Cellular Adhesion to Improve Clinical Care in Sickle Cell DiseaseR01HL133574 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GURKAN, UMUT A., LITTLE, JANE · 2016 to 2020
$2.0M
CWRU- Cardiovascular Research Training ProgramT32HL134622 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR, PROWELLER, AARON · 2017 to 2021
$1.9M
Portable, affordable, quantitative microchip electrophoresis for hemoglobin A1C testingR41DK119048 · NIDDK · HEMEX HEALTH, INC. · PI GALEN, PETER · 2018 to 2018
$225k
Portable, affordable, quantitative microchip electrophoresis system for integrated anemia and hemoglobin variant testingR41HL151015 · NHLBI · HEMEX HEALTH, INC. · PI GALEN, PETER · 2020 to 2020
$225k
NHLBI NIH HHS R01 HL133574NHLBI NIH HHS R41 HL151015NHLBI NIH HHS R44 HL140739NHLBI NIH HHS T32 HL134622NHLBI NIH HHS U54 HL143541NIDDK NIH HHS R41 DK119048
6 · The paper itself

Abstract

Anemia, characterized by low blood hemoglobin level, affects about 25% of the world's population with the heaviest burden borne by women and children. Anemia leads to impaired cognitive development in children, as well as high morbidity and early mortality among sufferers. Anemia can be caused by nutritional deficiencies, oncologic treatments and diseases, and infections such as malaria, as well as inherited hemoglobin or red cell disorders. Effective treatments are available for anemia upon early detection and the treatment method is highly dependent on the cause of anemia. There is a need for point-of-care (POC) screening, early diagnosis, and monitoring of anemia, which is currently not widely accessible due to technical challenges and cost, especially in low- and middle-income countries where anemia is most prevalent. This review first introduces the evolution of anemia detection methods followed by their implementation in current commercially available POC anemia diagnostic devices. Then, emerging POC anemia detection technologies leveraging new methods are reviewed. Finally, we highlight the future trends of integrating anemia detection with the diagnosis of relevant underlying disorders to accurately identify specific root causes and to facilitate personalized treatment and care.

Indexed as

AnemiaPoint-of-Care SystemsHemoglobinsHumansMass ScreeningHemoglobins

Identifiers

PMID33881041
PMCPMC8875318
OpenAlexW3140486334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.