Evidence map›Paper›PMID 33881010›Full record

ArticleLa Medicina del lavoro2021

Lead poisoning from Ayurvedic treatment: a further case.

Catalina Ciocan, Ihab Mansour, Alessandro Beneduce, Riccardo Corgiat Loia, Nicolò Milanesio, Michael Declementi, Alessandro Godono, Giacomo Garzaro, Enrico Pira

Open access · diamondAbstract readCase Reports
In one paragraph

Article in La Medicina del lavoro, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Catalina CiocanUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. catalina.ciocan@unito.it.
Ihab MansourUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. ihab.mansour@unito.it.
Alessandro BeneduceUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. alessandro.beneduce@unito.it.
Riccardo Corgiat LoiaUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. riccardo.corgiatloia@unito.it.
Nicolò MilanesioUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. nicolo.milanesio@unito.it.
Michael DeclementiUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. michael.declementi@unito.it.
Alessandro GodonoUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. alessandro.godono@unito.it.
Giacomo GarzaroUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. giacomo.garzaro@unito.it.
Enrico PiraUniversity of Torino, Department of Public Health and Pediatrics, Turin, Italy. enrico.pira@unito.it.
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe report a case of a 30 years old Indian sailor with microcytic anemia (Hb 9.9), persistent abdominal pain, emesis, dark stool, hyperchromic urine, latent jaundice and asthenia. Lead intoxication was confirmed (blood lead value of 102 μg/dL). The patient assumed Ayurvedic medicines in the previous months. Ayurveda is an ancient form of Indian traditional popular medicine aiming to re-establish health and body function through herbal preparations, heavy metals are often added. Our purpose was to treat the patient and to establish the source of poisoning.

methodsAfter testing blood and urine lead concentration of other 3 crew members and analyzing over than 150 products used on the ship professional exposure was excluded. We analyzed the two Ayurvedic drugs assumed by the patient with an Inductively Coupled Plasma Mass Spectrometry. The patient underwent three chelation cycles with Calcium Disodium Ethylenediaminetetraacetic acid (EDTA) while monitoring blood and urinary lead levels.

resultsThe final blood lead level at discharge, after three chelation cycles, was 36.27 μg/dL. One of the two drugs contained extremely high concentrations of lead and mercury. The three different mixtures of this preparation showed lead concentrations of 12,638.54 mg/kg (Sample 2A), 23,043.02 mg/kg (Sample 2B), 21,352.97 mg/kg (Sample 2C); these levels are much higher than the highest values reported in literature for the indian soil (32 mg/kg).

conclusionsThis case and similar cases raise the safety alert on complementary and alternative medicines; Ayurvedic medicine users should be carefully informed about potential risks and signs of poisoning.

Indexed as

Lead PoisoningMercuryAdultHumansLeadMedicine, AyurvedicPlant PreparationsLeadMercuryPlant Preparations

Identifiers

PMID33881010
PMCPMC8095331
OpenAlexW3156202839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.