Evidence map›Paper›PMID 33880968›Full record

ArticleCell transplantation

Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats.

Takashi Nakamura, Utako Yokoyama, Tomomitsu Kanaya, Takayoshi Ueno, Takanori Yoda, Atsushi Ishibe, Yuko Hidaka, Masanari Umemura, Toshio Takayama, Makoto Kaneko and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Takashi NakamuraCardiovascular Research Institute, 13155Yokohama City University, Yokohama, Kanagawa, Japan.
Utako YokoyamaCardiovascular Research Institute, 13155Yokohama City University, Yokohama, Kanagawa, Japan.ORCID 0000-0003-1803-0155
Tomomitsu KanayaDepartment of Cardiovascular Surgery, 38637Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Takayoshi UenoDepartment of Cardiovascular Surgery, 38637Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Takanori YodaCardiovascular Research Institute, 13155Yokohama City University, Yokohama, Kanagawa, Japan.
Atsushi IshibeDepartment of Gastroenterological Surgery, 13155Yokohama City University, Yokohama, Kanagawa, Japan.
Yuko HidakaCardiovascular Research Institute, 13155Yokohama City University, Yokohama, Kanagawa, Japan.ORCID 0000-0002-4890-6317
Masanari UmemuraCardiovascular Research Institute, 13155Yokohama City University, Yokohama, Kanagawa, Japan.
Toshio TakayamaDepartment of Mechanical Engineering, 13290Tokyo Institute of Technology, Tokyo, Japan.
Makoto KanekoGraduate School of Science and Engineering, 12942Meijo University, Nagoya, Aichi, Japan.
Shigeru MiyagawaDepartment of Cardiovascular Surgery, 38637Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yoshiki SawaDepartment of Cardiovascular Surgery, 38637Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Itaru EndoDepartment of Gastroenterological Surgery, 13155Yokohama City University, Yokohama, Kanagawa, Japan.
Yoshihiro IshikawaCardiovascular Research Institute, 13155Yokohama City University, Yokohama, Kanagawa, Japan.
Cardiovascular Institute Hospital · JPThe University of Osaka · JPYokohama City University · JPMeijo University · JPTokyo Institute of Technology · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal anastomotic leakage is one of the most feared and fatal complications of colorectal surgery. To date, no external coating material that can prevent anastomotic leakage has been developed. As myoblasts possess anti-inflammatory capacity and improve wound healing, we developed a multilayered human skeletal muscle myoblast (HSMM) sheet by periodic exposure to supraphysiological hydrostatic pressure during repeated cell seeding. We assessed whether the application of an HSMM sheet can promote the healing process after colonic anastomosis. Partial colectomy and insufficient suturing were employed to create a high-risk colo-colonic anastomosis model in 60 nude rats. Rats were divided into a control group (

Indexed as

Anastomosis, SurgicalAnimalsColonHumansMaleMiceMice, NudeMyoblasts, SkeletalRatsanastomotic leakagehydrostatic pressuremechanical stressskeletal myoblasttissue engineering

Identifiers

PMID33880968
PMCPMC8076781
OpenAlexW3155240697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.