Evidence map›Paper›PMID 33880959›Full record

Trial reportHand (New York, N.Y.)2022

Safety and Duration of Low-Dose Adjuvant Dexamethasone in Regional Anesthesia for Upper Extremity Surgery: A Prospective, Randomized, Controlled Blinded Study.

Nura Gouda, Julian Zangrilli, Armen Voskerijian, Mark L Wang, Pedro K Beredjiklian, Michael Rivlin

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hand (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06402149 (Comparison of 2 Different Methods in Infraclavicular Block), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06402149 enrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Comparison of 2 Different Methods in Infraclavicular Block

TypeobservationalSponsorAnkara City Hospital BilkentRan2023 to 2024Enrolled60ConditionsPostoperative Pain, Nerve Block, AnalgesicsArmsdexamethasone
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nura GoudaRothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.
Julian ZangrilliRowan School of Osteopathic Medicine, Stratford, NJ, USA.ORCID 0000-0003-2140-8024
Armen VoskerijianJefferson Surgery Center at the Navy Yard, Philadelphia, PA, USA.
Mark L WangRothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.
Pedro K BeredjiklianRothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.
Michael RivlinRothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.
Thomas Jefferson University · USBryn Mawr Hospital · USRowan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOrthopedic procedures concerning the upper extremity commonly use a brachial plexus nerve block to achieve postoperative analgesia. The addition of dexamethasone to peripheral nerve blocks has been shown to significantly prolong its effect. We hypothesize that 1 mg doses of dexamethasone will prolong brachial plexus nerve block with similar efficacy to 4 mg and better than ropivacaine alone.

methodsSeventy-nine patients who received a brachial plexus nerve block prior to undergoing upper extremity surgery were randomized to 1 of 4 treatment groups: group 1 received only 30 mL of 0.5% ropivacaine without dexamethasone (control); groups 2, 3, and 4 received 4, 2, and 1 mg of dexamethasone, respectively, added to 30 mL of 0.5% ropivacaine.

resultsComparison of block duration, specifically "first signs of the block wearing off" to the 0-mg group, referencing the 1-, 2-, and 4-mg groups (

conclusionsOur findings demonstrate that adjuvant dexamethasone can prolong brachial plexus nerve blocks effectively at low doses compared with high doses, in addition to prolonging analgesia compared with local anesthetic alone.

Indexed as

Anesthetics, LocalBrachial Plexus BlockDexamethasoneHumansPostoperative PainProspective StudiesRopivacaineUpper ExtremityAnesthetics, LocalDexamethasoneRopivacaineanesthesiabasic sciencediagnosisnervepainpain managementspecialtysurgery

Identifiers

PMID33880959
PMCPMC9608287
OpenAlexW3156642420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.