ArticleHand (New York, N.Y.)2023
Acellular Nerve Allografts in Major Peripheral Nerve Repairs: An Analysis of Cases Presenting With Limited Recovery.
Article in Hand (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Modulation of the regenerative microenvironment within acellular nerve allografts using tacrolimus improves nerve regeneration.Neural regeneration research · 2026Article
- Application strategies of autologous and decellularized nerve grafts: Structural and functional recovery.Neural regeneration research · 2026Article
- Peripheral Nerve Decellularisation Protocol for Allogeneic Transplantation: From Tissue Procurement to Banking.International journal of molecular sciences · 2025Article
- Motor Function in the Setting of Nerve Allografts: Is This the Future of Facial Nerve Reconstruction?Journal of clinical medicine · 2025Review
- Engineering the Future of Restorative Clinical Peripheral Nerve Surgery.Advanced healthcare materials · 2025Review
- Utilizing Intercostal Nerve Autografts for Nipple Neurotization: A Novel Approach to Restore Sensation.Plastic and reconstructive surgery. Global open · 2025Article
- Berberine Enhances Neuroregeneration in a Rat Model of Peroneal Nerve Transection Injury: An Animal Study.Journal of pain research · 2025Article
- Use of a Pedicled Vascularized Ulnar Nerve as a Long Graft for Complete Brachial Plexus Palsy in Adults to Restore Elbow Flexion: Should this Practice Continue?Journal of brachial plexus and peripheral nerve injury · 2025Article
- Nerve Autografts Versus Allografts for Mixed Motor/Sensory Nerve Reconstruction.Journal of hand surgery global online · 2024Review
- Management of "Long" Nerve Gaps.Journal of hand surgery global online · 2024Article
- Current Concepts in Brachial Plexus Birth Injuries: A Comprehensive Narrative Review.Plastic and reconstructive surgery. Global open · 2024Article
- Imaging the Nerve "Allograft to Muscle Target" Technique in Neuroma Management.Plastic and reconstructive surgery. Global open · 2024Article
- Biohacking Nerve Repair: Novel Biomaterials, Local Drug Delivery, Electrical Stimulation, and Allografts to Aid Surgical Repair.Bioengineering (Basel, Switzerland) · 2024Review
- Limited Nerve Regeneration across Acellular Nerve Allografts (ANAs) Coincides with Changes in Blood Vessel Morphology and the Development of a Pro-Inflammatory Microenvironment.International journal of molecular sciences · 2024Article
- Evaluation of Processed Nerve Allograft in Peripheral Nerve Surgery: A Systematic Review and Critical Appraisal.Plastic and reconstructive surgery. Global open · 2023Article
- ComprehensiveFrontiers in bioengineering and biotechnology · 2023Article
- Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep.Cells · 2022Article
- Effect of acellular nerve scaffold containing human umbilical cord-derived mesenchymal stem cells on nerve repair and regeneration in rats with sciatic nerve defect.Annals of translational medicine · 2022Article
- A Retrospective Case Series of Peripheral Mixed Nerve Reconstruction Failures Using Processed Nerve Allografts.Plastic and reconstructive surgery. Global open · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcellular nerve allografts have been used successfully and with increasing frequency to reconstruct nerve injuries. As their use has been expanded to treat longer gap, larger diameter nerve injuries, some failed cases have been reported. We present the histomorphometry of 5 such cases illustrating these limitations and review the current literature of acellular nerve allografts.
methodsBetween 2014 and 2019, 5 patients with iatrogenic nerve injuries to the median or ulnar nerve reconstructed with an AxoGen AVANCE nerve allograft at an outside hospital were treated in our center with allograft excision and alternative reconstruction. These patients had no clinical or electrophysiological evidence of recovery, and allograft specimens at the time of surgery were sent for histomorphological examination.
resultsThree patients with a median and 2 with ulnar nerve injury were included. Histology demonstrated myelinated axons present in all proximal native nerve specimens. In 2 cases, axons failed to regenerate into the allograft and in 3 cases, axonal regeneration diminished or terminated within the allograft.
conclusionsThe reported cases demonstrate the importance of evaluating the length and the function of nerves undergoing acellular nerve allograft repair. In long length, large-diameter nerves, the use of acellular nerve allografts should be carefully considered.
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