ArticleJournal of the American Heart Association2021
Electrocardiographic Imaging of Repolarization Abnormalities.
Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The influence of delayed ventricular activation on cardiac repolarization: Insights from electrocardiographic imaging.The Journal of physiology · 2026Article
- Computer-aided characterization of the arrhythmogenic substrate after myocardial infarction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Review
- The contribution of a short electrocardiographic diastolic interval to diastolic dysfunction and HFpEF.BMC cardiovascular disorders · 2025Article
- Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Reference for Electrocardiographic Imaging-Based T-Wave Alternans Estimation.IEEE access : practical innovations, open solutions · 2024Article
- Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited.Frontiers in physiology · 2023Article
- Tipping the scales of understanding: An engineering approach to design and implement whole-body cardiac electrophysiology experimental models.Frontiers in physiology · 2023Article
- Investigation into the importance of using natural PVCs and pathological models for potential-based ECGI validation.Frontiers in physiology · 2023Article
- Basis and applicability of noninvasive inverse electrocardiography: a comparison between cardiac source models.Frontiers in physiology · 2023Review
- Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T-wave parameters.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Article
- State-of-the-Art Multimodality Imaging in Sudden Cardiac Arrest with Focus on Idiopathic Ventricular Fibrillation: A Review.Journal of clinical medicine · 2022Review
- Noninvasive Mapping of Repolarization With Electrocardiographic Imaging.Journal of the American Heart Association · 2021Article
- Electrocardiographic Imaging of Repolarization Abnormalities.Journal of the American Heart Association · 2021Article
- Article
- Dispersion of repolarization increases with cardiac resynchronization therapy and is associated with left ventricular reverse remodeling.Journal of electrocardiologyArticle
Corrections and comments
- Commented on by
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Dispersion and gradients in repolarization have been associated with life-threatening arrhythmias, but are difficult to quantify precisely from surface electrocardiography. The objective of this study was to evaluate electrocardiographic imaging (ECGI) to noninvasively detect repolarization-based abnormalities. Methods and Results Ex vivo data were obtained from Langendorff-perfused pig hearts (n=8) and a human donor heart. Unipolar electrograms were recorded simultaneously during sinus rhythm from an epicardial sock and the torso-shaped tank within which the heart was suspended. Regional repolarization heterogeneities were introduced through perfusion of dofetilide and pinacidil into separate perfusion beds. In vivo data included torso and epicardial potentials recorded simultaneously in anesthetized, closed-chest pigs (n=5), during sinus rhythm, and ventricular pacing. For both data sets, ECGI accurately reconstructed T-wave electrogram morphologies when compared with those recorded by the sock (ex vivo: correlation coefficient, 0.85 [0.52-0.96], in vivo: correlation coefficient, 0.86 [0.52-0.96]) and repolarization time maps (ex-vivo: correlation coefficient, 0.73 [0.63-0.83], in vivo: correlation coefficient, 0.76 [0.67-0.82]). ECGI-reconstructed repolarization time distributions were strongly correlated to those measured by the sock (both data sets,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.