ReviewJournal of the American Chemical Society2021
Illuminating Life's Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules.
Review in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- On-Demand Photoprotection by UV-Transparent Small Molecules via Aggregation-Induced Absorption: The Origin and Modern Application.ACS central science · 2026Article
- UV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Shadow of a Shadow: Ferrocyanide and Nitroprusside as Sunscreens for Photosensitive Prebiotic Molecules.Life (Basel, Switzerland) · 2026Article
- Organocatalytic atom transfer radical polymerization with light and pH dual-gated regulation.Nature communications · 2026Article
- Strand Structure Controls Photoinduced Self-Repair of RNA Uracil Dimers.The journal of physical chemistry letters · 2026Article
- Redox chemistry of early Earth and the origin of life.Communications chemistry · 2026Review
- Complex and Messy Prebiotic Chemistry: Obstacles and Opportunities for an RNA World.Life (Basel, Switzerland) · 2026Review
- Protic small molecule bioregulators.Redox biology · 2025Review
- Efficient Assembly of Functional RNA byJournal of the American Chemical Society · 2025Article
- Preferential survival of prebiotic metallopeptides in the presence of ultraviolet light.Chemical science · 2025Article
- Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem : a European journal of chemical biology · 2025Review
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- On the Origin of Information Dynamics in Early Life.Life (Basel, Switzerland) · 2025Article
- Recent advances in the synthesis, reaction, and bio-evaluation potential of purines as precursor pharmacophores in chemical reactions: a review.RSC advances · 2025Review
- Selection of Early Life Codons by Ultraviolet Light.ACS central science · 2025Article
- Do-Nothing Prebiotic Chemistry: Chemical Kinetics as a Window into Prebiotic Plausibility.Accounts of chemical research · 2025Article
- Groundwater-Driven Evolution of Prebiotic Alkaline Lake Environments.Life (Basel, Switzerland) · 2024Article
- Wet-dry cycles cause nucleic acid monomers to polymerize into long chains.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Solvothermal Polymerization of Diaminomaleonitrile Reveals Optimal Green Solvents for the Production of C=N-Based Polymers.ACS omega · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Solar radiation is the principal source of energy available to Earth and has unmatched potential for the synthesis of organic material from primordial molecular building blocks. As well as providing the energy for photochemical synthesis of (proto)biomolecules of interest in origins of life-related research, light has also been found to often provide remarkable selectivity in these processes, for molecules that function in extant biology and against those that do not. As such, light is heavily implicated as an environmental input on the nascent Earth that was important for the emergence of complex yet selective chemical systems underpinning life. Reactivity and selectivity in photochemical prebiotic synthesis are discussed, as are their implications for origins of life scenarios and their plausibility, and the future directions of this research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.