Evidence map›Paper›PMID 33880728›Full record

Observational studyCanadian journal of anaesthesia = Journal canadien d'anesthesie2021

Hypoxemia during procedural sedation in adult patients: a retrospective observational study.

Eva P C van Schaik, Paul Blankman, Wilton A Van Klei, Hans J T A Knape, Paul H H B Vaessen, Sue A Braithwaite, Leo van Wolfswinkel, Willem-Jan M Schellekens

2 registry-linked trialsOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05708651 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Tematic Evaluation of a New Medical Device (STAIRWAY) for Open Airways

TypeinterventionalSponsorStairway Medical ABRan2023 to 2024Enrolled56ConditionsAirway Obstruction, Sedation Complication, Safety Issues, Patient SatisfactionArmsInvestigational device [I-IV], Comparator [I-IV]
NCT07059728 narecruitingnot on this mapstarted 2025, after this paper: background citation

Uso de Lentillas de Alto Flujo en Procedimientos de sustitución de válvula aórtica transcatéter. Impacto en Las Complicaciones Respiratorias y Biomarcado- Res y Resultados clínicos. TAVR-Highflow

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2025 to 2027Enrolled452ConditionsAortic Stenosis Treated With TAVI, Sedation, Aged, HemodynamicsArmsOxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. High-flow nasal oxygen in anesthesiology practice.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Eva P C van SchaikSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Paul BlankmanSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands. p.blankman-3@umcutrecht.nl.ORCID http://orcid.org/0000-0002-7024-0611
Wilton A Van KleiSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Hans J T A KnapeSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Paul H H B VaessenSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Sue A BraithwaiteSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Leo van WolfswinkelSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Willem-Jan M SchellekensSection of vital functions, Department of Anesthesiology, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands.
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSince 2010, new guidelines for procedural sedation and the Helsinki Declaration on Patient Safety have increased patient safety, comfort, and acceptance considerably. Nevertheless, the administration of sedatives and opioids during sedation procedures may put the patient at risk of hypoxemia. However, data on hypoxemia during procedural sedation are scarce. Here, we studied the incidence and severity of hypoxemia during procedural sedations in our hospital.

methodsA historical, single-centre cohort study was performed at the University Medical Centre Utrecht (UMCU), a tertiary centre in the Netherlands. Data from procedural sedation in our hospital between 1 January 2011 and 31 December 2018 (3,459 males and 2,534 females; total, 5,993) were extracted from our Anesthesia Information Management System. Hypoxemia was defined as peripheral oxygen saturation < 90% lasting at least two consecutive minutes. The severity of hypoxemia was calculated as area under the curve. The relationship between the severity of hypoxemia and body mass index (BMI), American Society of Anesthesiologists (ASA) Physical Status classification, and duration of the procedure was investigated. The primary outcome was the incidence of hypoxemia.

resultsTwenty-nine percent of moderately to deeply sedated patients developed hypoxemia. A high incidence of hypoxemia was found in patients undergoing procedures in the heart catheterization room (54%) and in patients undergoing bronchoscopy procedures (56%). Hypoxemia primarily occurred in longer lasting procedures (> 120 min) and especially in the latter phases of the procedures. There was no relationship between severity of hypoxemia and BMI or ASA Physical Status.

conclusionsThis study showed that a considerable number of patients are at risk of hypoxemia during procedural sedation with a positive correlation shown with increasing duration of medical procedures. Additional prospective research is needed to investigate the clinical consequences of this cumulative hypoxemia.

Indexed as

AnesthesiaHypoxiaAdultCohort StudiesFemaleHumansHypnotics and SedativesMaleProcedural SedationProspective StudiesRetrospective StudiesHypnotics and Sedativeshypoxemiaprocedural sedationrespiratory complicationssafety

Identifiers

PMID33880728
PMCPMC8376691
OpenAlexW3153591617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.