Evidence map›Paper›PMID 33880672›Full record

ArticleMolecular biology reports2021

Effect of ethanol and cocaine on [

Naresh Damuka, Miranda Orr, Paul W Czoty, Jeffrey L Weiner, Thomas J Martin, Michael A Nader, Avinash H Bansode, Buddhika S Liyana Pathirannahel, Akiva Mintz, Shannon L Macauley and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

  1. Imaging Microtubule Dynamics In Vivo in Human Brain: Optimal Quantification Based on a Test-Retest Study.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Review
  3. Imaging microtubule dynamics: A new frontier in biomarker development for neurodegenerative diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. [Pharmacological reports : PR · 2025
    Article
  5. Article
  6. Article
  7. Exploring microtubule dynamics in Alzheimer's disease: Longitudinal assessment using [Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  8. Article
  9. Binding Parameters of [Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  10. Article
  11. [Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Naresh DamukaDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Miranda OrrDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Paul W CzotyDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jeffrey L WeinerDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Thomas J MartinDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Michael A NaderDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Avinash H BansodeDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Buddhika S Liyana PathirannahelDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Shannon L MacauleyDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Suzanne CraftDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kiran Kumar Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA. ksolinga@wakehealth.edu.
Wake Forest University · USColumbia University Irving Medical Center · US

Funding

Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jeffrey L. Weiner · 2018 to 2026
$16.2M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WILLIAMSON, JEFF DOUGLAS · 2016 to 2020
$12.2M
Mechanisms Mediating Cocaine Abuse in Socially Housed Female and Male MonkeysR01DA017763 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael A Nader · 2004 to 2026
$9.8M
The metabolic interplay of sleep and Alzheimer's diseaseR01AG068330 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MACAULEY-RAMBACH, SHANNON L · 2020 to 2024
$3.5M
Synaptic Correlates of Vulnerability and Resilience to Alcohol Use DisordersR37AA017531 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEINER, JEFFREY L. · 2014 to 2023
$3.5M
Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's diseaseR01AG065839 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLINGAPURAM SAI, KIRAN · 2020 to 2024
$2.5M
NIAAA NIH HHS P50 AA026117NIAAA NIH HHS R37 AA017531NIA NIH HHS P30 AG049638NIA NIH HHS R01 AG065839NIA NIH HHS R01 AG068330NIDA NIH HHS DA017763NIDA NIH HHS R01 DA017763
6 · The paper itself

Abstract

Microtubules (MTs) are structural units in the cytoskeleton. In brain cells they are responsible for axonal transport, information processing, and signaling mechanisms. Proper function of these processes is critical for healthy brain functions. Alcohol and substance use disorders (AUD/SUDs) affects the function and organization of MTs in the brain, making them a potential neuroimaging marker to study the resulting impairment of overall neurobehavioral and cognitive processes. Our lab reported the first brain-penetrant MT-tracking Positron Emission Tomography (PET) ligand [

Indexed as

Carbon RadioisotopesCell Line, TumorCentral Nervous System AgentsCocaineEthanolHumansMicrotubulesNeuronsProtein BindingQuinazolinesRadiopharmaceuticalsTubulinTubulin ModulatorsCarbon RadioisotopesCentral Nervous System AgentsCocaineEthanolQuinazolinesRadiopharmaceuticalsTubulinTubulin ModulatorsverubulinBiomarkersCytoskeletonIn vitro bindingMicrotubuleSubstance use disorder

Identifiers

PMID33880672
PMCPMC8172511
OpenAlexW3153366633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.