Evidence map›Paper›PMID 33880636›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Functional and oncological outcomes of salvage transoral robotic surgery: a comparative study.

Pierre Gazda, Clément Gauche, Léonor Chaltiel, Emilien Chabrillac, Benjamin Vairel, Guillaume De Bonnecaze, Agnès Dupret-Bories, Thomas Filleron, Sébastien Vergez

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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pierre GazdaDepartment of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France. pierre.gazda@gmail.com.ORCID http://orcid.org/0000-0003-4952-9610
Clément GaucheDepartment of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Léonor ChaltielDepartment of Biostatistics, Institut Claudius Regaud, IUCT Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Emilien ChabrillacDepartment of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Benjamin VairelDepartment of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Guillaume De BonnecazeDepartment of ENT Head and Neck Surgery, CHU Larrey, 24 chemin de Pourvourville, 31400, Toulouse, France.
Agnès Dupret-BoriesDepartment of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Thomas FilleronDepartment of Biostatistics, Institut Claudius Regaud, IUCT Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Sébastien VergezDepartment of ENT Head and Neck Surgery, Institut Claudius Regaud, IUCT-Oncopole, 1 Av. Irène Joliot-Curie, 31059, Toulouse, France.
Hôpital Larrey · FRInstitut Claudius Regaud · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTransoral robotic surgery (TORS) as a first-line therapy has been well-documented but evidence is missing regarding salvage therapy. The aim of this study is to compare the oncological and functional outcomes of TORS as a primary and salvage therapy.

methodsThis retrospective monocentric study included 74 patients operated by a single surgeon and sorted out into two groups: primary treatment (PT) or Salvage treatment (ST) in case of previous history of radiation therapy. Patients were further stratified by tumour location: larynx and pharynx (lST vs lPT and pST vs pPT).

resultsForty-eight patients were included in PT group (64.9%) and 26 in ST group (35.1%). ST patients had more frequent cTis/T1 tumours (57.7% vs 29.2%, p = 0.0164) and no clinical lymph disease (3.8% vs 37.5%, p = 0.0016). Tracheostomy was more often performed in the ST group (57.7% vs 16.7%, p = 0.0003) and the lST subgroup (88.9% vs 9.1%, p < 0.0001). Gastric feeding tube placement was more frequent in the ST group (76.9% vs 33.3%, p = 0.0003), the pST subgroup (64.7% vs 15.4%, p = 0.0009) and the lST subgroup (100% vs 54.5%, p = 0.0297). We observed a trend for more postoperative complications in the ST group (69.2% vs 47.9%, p = 0.0783). The overall survival was lower in the ST group (p = 0.0004), and in the pST subgroup (p < 0.0001). The disease-free survival rate was lower in the ST group (p = 0.0001), the pST subgroup (p = 0.0002) and the lST subgroup (p = 0.0328).

conclusionThis study confirms that survival and functional outcomes after salvage TORS are worse than in first line surgery.

Indexed as

Oropharyngeal NeoplasmsRobotic Surgical ProceduresDisease-Free SurvivalHumansRetrospective StudiesSalvage TherapyTreatment OutcomeHead and neck cancerSalvage treatmentSwallowing disordersTracheostomyTransoral robotic surgery

Identifiers

PMID33880636
OpenAlexW3155654802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.