ArticleAnnals of biomedical engineering2021
Anisotropic Mechanical Properties of the Human Uterus Measured by Spherical Indentation.
Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Extracellular matrix composition and stiffness regulates progesterone responsiveness and decidualization.iScience · 2026Article
- Seedling fibroid characterization using optical coherence tomography.Biomedical optics express · 2026Article
- A finite element model of pregnancy derived from maternal sonography: effect of uterine and cervical structural properties on cervical mechanical loading.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of stiffness values of normal uterine myometrium by 3T magnetic resonance elastography.Frontiers in medicine · 2026Article
- Overcoming Mechanical Blindness: Adaptive Surgical Instrument Design for the Heterogeneous Landscape of Uterine Fibroids.Research (Washington, D.C.) · 2026Review
- Microstructure-Informed Hyper-Viscoelastic Model Capturing Soft Tissue Tensile Behavior Across Large Deformations.Journal of the mechanics and physics of solids · 2026Article
- Mechanical Cues Regulate Estrogen and Progesterone-Induced Nascent ECM Deposition by Human Endometrial Stromal Cells.bioRxiv : the preprint server for biology · 2025Article
- Time-dependent material properties and composition of the nonhuman primate uterine layers through gestation.Scientific reports · 2025Article
- Time-Dependent Material Properties and Composition of the Nonhuman Primate Uterine Layers Through Gestation.bioRxiv : the preprint server for biology · 2025Article
- Equilibrium mechanical properties of the human uterus in tension and compression.Acta biomaterialia · 2025Article
- Finite element modeling in obstetrics and gynecology: advances, applications, and challenges.Frontiers in medicine · 2025Review
- Review
- Article
- Equilibrium Mechanical Properties of the Nonhuman Primate Cervix.Journal of biomechanical engineering · 2024Article
- On the uncertainty quantification of the active uterine contraction during the second stage of labor simulation.Medical & biological engineering & computing · 2024Article
- Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease†.Biology of reproduction · 2024Review
- Equilibrium Tension and Compression Mechanical Properties of the Human Uterus.bioRxiv : the preprint server for biology · 2024Article
- Material properties of nonpregnant and pregnant human uterine layers.Journal of the mechanical behavior of biomedical materials · 2024Article
- Multiphysics and multiscale modeling of uterine contractions: integrating electrical dynamics and soft tissue deformation with fiber orientation.Medical & biological engineering & computing · 2024Article
- Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk.Med (New York, N.Y.) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanical function of the uterus is critical for a successful pregnancy. During gestation, uterine tissue grows and stretches to many times its size to accommodate the growing fetus, and it is hypothesized the magnitude of uterine tissue stretch triggers the onset of contractions. To establish rigorous mechanical testing protocols for the human uterus in hopes of predicting tissue stretch during pregnancy, this study measures the anisotropic mechanical properties of the human uterus using optical coherence tomography (OCT), instrumented spherical indentation, and video extensometry. In this work, we perform spherical indentation and digital image correlation to obtain the tissue's force and deformation response to a ramp-hold loading regimen. We translate previously reported fiber architecture, measured via optical coherence tomography, into a constitutive fiber composite material model to describe the equilibrium material behavior during indentation. We use an inverse finite element method integrated with a genetic algorithm (GA) to fit the material model to our experimental data. We report the mechanical properties of human uterine specimens taken across different anatomical locations and layers from one non-pregnant (NP) and one pregnant (PG) patient; both patients had pathological uterine tissue. Compared to NP uterine tissue, PG tissue has a more dispersed fiber distribution and equivalent stiffness material parameters. In both PG and NP uterine tissue, the mechanical properties differ significantly between anatomical locations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.