ArticleApplied microbiology and biotechnology2021
Metabolomic analyses revealed multifaceted effects of hexanal on Aspergillus flavus growth.
Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- New Contributions to Deepen the Quality-Based Safety Assessment in the Consumption of Edible Nasturtium Flowers-The Role of Volatilome.Life (Basel, Switzerland) · 2025Article
- Anti-Foods (Basel, Switzerland) · 2025Article
- Characteristics and functions of volatile organic compounds in the tripartite symbiotic system ofPlant signaling & behavior · 2024Article
- Protection of postharvest grains from fungal spoilage by biogenic volatiles.Applied microbiology and biotechnology · 2023Review
- Changes of gut microbiota and tricarboxylic acid metabolites may be helpful in early diagnosis of necrotizing enterocolitis: A pilot study.Frontiers in microbiology · 2023Article
- Impact of Volatile Organic Compounds on the Growth ofInternational journal of molecular sciences · 2022Review
- Antifungal mechanism of 1-nonanol against Aspergillus flavus growth revealed by metabolomic analyses.Applied microbiology and biotechnology · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hexanal, a natural volatile organic compound, exerts antifungal activity against Aspergillus flavus; however, the mechanisms underlying these effects are unclear. In this study, we found that the growth of A. flavus mycelium was completely inhibited following exposure to 0.4 μL/mL hexanal (minimal inhibitory concentration). A detailed metabolomics survey was performed to identify changes in metabolite production by A. flavus cells after exposure to 1/2 the minimal inhibitory concentration of hexanal for 6 h, which revealed significant differences in 70 metabolites, including 20 upregulated and 50 downregulated metabolites. Among them, levels of L-malic acid, α-linolenic acid, phosphatidylcholine, D-ribose, riboflavin, D-mannitol, D-sorbitol, and deoxyinosine were significantly reduced. The metabolomics results suggest that the metabolites are mainly involved in the tricarboxylic acid cycle (TCA), ABC transport system, and membrane synthesis in A. flavus cells. Hexanal treatment reduced succinate dehydrogenase and mitochondrial dehydrogenase activity and stimulated superoxide anion and hydrogen peroxide accumulation in A. flavus mycelia. Increases in the electric conductivity and A
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