Evidence map›Paper›PMID 33880593›Full record

ArticleMolecular medicine reports2021

lncRNA FGD5‑AS1 promotes breast cancer progression by regulating the hsa‑miR‑195‑5p/NUAK2 axis.

Kun Fang, Zheng-Jie Xu, Su-Xiao Jiang, De-Sheng Tang, Chang-Sheng Yan, You-Yuan Deng, Fu-Ying Zhao

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. NUAK: never underestimate a kinase.Essays in biochemistry · 2024
    Review
  4. Long noncoding RNA TMPO-AS1 upregulates BCAT1 expression to promote cell proliferation in nasopharyngeal carcinoma via microRNA let-7c-5p.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kun Fang *Department of Surgery, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, P.R. China.
Zheng-Jie Xu *Department of Surgery, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, P.R. China.
Su-Xiao JiangDepartment of Surgery, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, P.R. China.
De-Sheng TangDepartment of Surgical Oncology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
Chang-Sheng YanDepartment of Surgical Oncology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.
You-Yuan DengDepartment of Surgery, Xiangtan Central Hospital, Xiangtan, Hunan 411100, P.R. China.
Fu-Ying ZhaoDepartment of Gynecology, Yinchuan Maternal and Child Health Hospital, Yinchuan, Ningxia 750001, P.R. China.
Yinchuan First People's Hospital · CNFirst Affiliated Hospital of Harbin Medical University · CNXiangyang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the second most prevalent cancer in women worldwide. Long non‑coding RNAs (lncRNAs) have been identified as important regulators of tumorigenesis and tumor metastasis. lncRNA FGD5‑AS1 has been previously reported as a carcinogenic gene, however its role in breast cancer has yet to be investigated. The present study aimed to understand the function of lncRNA FGD5‑AS1 in breast cancer and examine the underlying molecular mechanisms. Sample tissues for downstream gene expression profiling were collected from patients with breast cancer (n=23). The effect of FGD5‑AS1 overexpression on cell viability, invasion and migration has been studied in breast cancer cells (MDA‑MB‑231). Changes in glycolysis were monitored by comparing glucose consumption, lactate production and ATP levels. Using StarBase and TargetScan databases a putative interaction between FGD5‑AS1, miR‑195‑5p and SNF1‑like kinase 2 (NUAK2) was predicted

Indexed as

BreastBreast NeoplasmsCell Line, TumorCell MovementCell ProliferationCell SurvivalFemaleGene Expression Regulation, NeoplasticGlycolysisGuanine Nucleotide Exchange FactorsHumansMicroRNAsProtein Serine-Threonine KinasesRNA, Long NoncodingFGD5 protein, humanGuanine Nucleotide Exchange FactorsMicroRNAsMIRN195 microRNA, humanNUAK2 protein, humanProtein Serine-Threonine KinasesRNA, Long NoncodingSIK1 protein, humanbreast cancerglycolysisncRNA FGD5‑AS1sa‑miR‑195‑5pSNF1‑like kinase 2

Identifiers

PMID33880593
PMCPMC8072314
OpenAlexW3153183704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.