Evidence map›Paper›PMID 33880570›Full record

ArticleJournal of rehabilitation medicine2021

Management of gait impairments in people with Charcot-Marie-Tooth disease: A treatment algorithm.

Jorik Nonnekes, Cheriel Hofstad, Annemieke de Greef-Rotteveel, Heleen van der Wielen, Janke H van Gelder, Christian Plaats, Viola Altmann, Fabian Krause, Noël Keijsers, Alexander Geurts and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of rehabilitation medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Is gaitrite system sensitive in discriminating gait pattern of subjects affected by Charcot Marie tooth? A pilot study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  5. Review
  6. Article
  7. Effects of intensive rehabilitation on functioning in patients with mild and moderate Charcot-Marie-Tooth disease: a real-practice retrospective study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Role of formin INF2 in human diseases.Molecular biology reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Jorik NonnekesDepartment of Rehabilitation, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, 6541GX Nijmegen, The Netherlands. E-mail: jorik.nonnekes@radboudumc.nl.
Cheriel Hofstad
Annemieke de Greef-Rotteveel
Heleen van der Wielen
Janke H van Gelder
Christian Plaats
Viola Altmann
Fabian Krause
Noël Keijsers
Alexander Geurts
Jan Willem K Louwerens
Sint Maartenskliniek · NLMedizinische Hochschule Hannover · DERadboud University Medical Center · NLRadboud University Nijmegen · NLSint Maartenskliniek · NLUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gait impairments in people with Charcot Marie Tooths disease are the combined result of ankle-foot deformities, muscle weakness, and somatosensory impairments. People with Charcot-Marie-Tooth disease often experience pain and difficulties when walking, especially barefoot. They also trip and fall frequently and have a lower than normal gait speed and distance. Because these gait impairments and related complaints are disabling, clinical management aimed at improving gait is important. Management involves both conservative and surgical treatment options, each with limited scientific evidence. However, a treatment algorithm that describes both conservative and surgical treatment options is currently lacking. This study sets out a step-wise treatment algorithm, based on evidence, if available, and otherwise reflecting practice-based experience. The treatment algorithm will be of value in daily clinical practice, and will serve as a template for future research.

Indexed as

AdolescentAlgorithmsCharcot-Marie-Tooth DiseaseChildFemaleGaitGait Disorders, NeurologicHumansMaleWalkingCharcot-Marie-Tooth diseasegaitrehabilitationsurgery

Identifiers

PMID33880570
PMCPMC8814859
OpenAlexW3155086509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.