Evidence map›Paper›PMID 33880550›Full record

ArticleThe Journal of nutrition2021

Association Between Added Sugars from Infant Formulas and Rapid Weight Gain in US Infants and Toddlers.

Kai Ling Kong, Brenda Burgess, Katherine S Morris, Tyler Re, Holly R Hull, Debra K Sullivan, Rocco A Paluch

Open access · greenAbstract read
In one paragraph

Article in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  7. US infant formulas contain primarily added sugars: An analysis of infant formulas on the US market.Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems · 2025
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  18. An Exploratory Qualitative Study of Beverage Sweetening Practices in Middle Eastern Families.Inquiry : a journal of medical care organization, provision and financing
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Kai Ling KongBaby Health Behavior Lab, Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Children's Mercy Hospital, Kansas City, MO, USA.
Brenda BurgessDivision of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Katherine S MorrisDivision of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
Tyler ReBaby Health Behavior Lab, Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Children's Mercy Hospital, Kansas City, MO, USA.
Holly R HullDepartment of Dietetics and Nutrition, Kansas University Medical Center, University of Kansas, Kansas City, KS, USA.
Debra K SullivanDepartment of Dietetics and Nutrition, Kansas University Medical Center, University of Kansas, Kansas City, KS, USA.
Rocco A PaluchDivision of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
University at Buffalo, State University of New York · USMercy Research · USUniversity Medical Center · USUniversity of Kansas Medical Center · US

Funding

Enhancing alternatives to eating in infancyR01HD087082 · NICHD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI EPSTEIN, LEONARD H, KONG, KAI LING · 2016 to 2020
$2.7M
NICHD NIH HHS R01 HD087082
6 · The paper itself

Abstract

backgroundFormulas often contain high amounts of added sugars, though little research has studied their connection to obesity.

objectivesThis study assessed the contribution of added sugars from formulas during complementary feeding on total added sugar intakes, and the association between these sugars and upward weight-for-age percentile (WFA%) crossing (i.e., participants crossing a higher threshold percentile were considered to have an upward crossing).

methodsData from three 24-hour dietary recalls for infants (n = 97; 9-12 months) and toddlers (n = 44; 13-15 months) were obtained in this cross-sectional analysis. Foods and beverages with added sugars were divided into 17 categories. Pearson's correlations were used to test relations between added sugar intake and upward WFA% crossing, followed by multivariable regressions when significant. ANOVA compared intakes of all, milk-based, and table foods between primarily formula-fed compared with breastfed participants. Multivariable regressions were used to test effects of added sugars and protein from all foods compared with added sugars and protein from milk-based sources on upward WFA% crossing.

resultsAdded sugars from formulas comprised 66% and 7% of added sugars consumed daily by infants and toddlers, respectively. A significant association was observed between upward WFA% crossing and added sugars from milk-based sources after controlling for gestational age, sex, age, introduction to solid foods, mean energy intakes, and maternal pre-pregnancy BMI and education (β = 0.003; 95% CI, 0.000-0.007; P = 0.046). Primarily formula-fed participants consumed nearly twice the energy from added sugars (P = 0.003) and gained weight faster (upward WFA% crossing = 1.1 ± 1.2 compared with 0.3 ± 0.6, respectively; P < 0.001) than their breastfed counterparts.

conclusionsAdded sugars in formulas predict rapid weight gain in infants and toddlers. Educating mothers on lower-sugar options may enhance childhood obesity prevention.

Indexed as

Infant FormulaPediatric ObesityWeight GainChild, PreschoolCross-Sectional StudiesDietary SugarsEnergy IntakeFemaleHumansInfantInfant Nutritional Physiological PhenomenaPregnancyDietary Sugarsadded sugarschildhood obesitycomplementary feedinginfant formulainfant rapid weight gain

Identifiers

PMID33880550
PMCPMC8169810
OpenAlexW3154270033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.